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Evaluation of polyvinyl alcohol composite membranes containing collagen and bone particles

Hameed, Nishar, Glattauer, Veronica and Ramshaw, John A. 2015, Evaluation of polyvinyl alcohol composite membranes containing collagen and bone particles, Journal of the mechanical behavior biomedical materials, vol. 48, pp. 38-45, doi: 10.1016/j.jmbbm.2015.04.005.

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Title Evaluation of polyvinyl alcohol composite membranes containing collagen and bone particles
Author(s) Hameed, Nishar
Glattauer, Veronica
Ramshaw, John A.
Journal name Journal of the mechanical behavior biomedical materials
Volume number 48
Start page 38
End page 45
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-08
ISSN 1878-0180
Keyword(s) Bone
Cell culture
Demineralised bone
Mechanical properties
Polyvinyl alcohol
Thermal properties
Science & Technology
Technology
Engineering, Biomedical
Materials Science, Biomaterials
Engineering
Materials Science
POLY(VINYL ALCOHOL)
ALCOHOL/COLLAGEN HYDROGEL
MORPHOGENETIC PROTEINS
GROWTH-FACTORS
IN-VIVO
MATRIX
BIOMATERIALS
BLENDS
FILMS
OSTEOINDUCTIVITY
Summary Composite biomaterials provide alternative materials that improve on the properties of the individual components and can be used to replace or restore damaged or diseased tissues. Typically, a composite biomaterial consists of a matrix, often a polymer, with one or more fillers that can be made up of particles, sheets or fibres. The polymer matrix can be chosen from a wide range of compositions and can be fabricated easily and rapidly into complex shapes and structures. In the present study we have examined three size fractions of collagen-containing particles embedded at up to 60% w/w in a poly(vinyl alcohol) (PVA) matrix. The particles used were bone particles, which are a mineral-collagen composite and demineralised bone, which gives naturally cross-linked collagen particles. SEM showed well dispersed particles in the PVA matrix for all concentrations and sizes of particles, with FTIR suggesting collagen to PVA hydrogen bonding. Tg of membranes shifted to a slightly lower temperature with increasing collagen content, along with a minor amount of melting point depression. The modulus and tensile strength of membranes were improved with the addition of both particles up to 10 wt%, and were clearly strengthened by the addition, although this effect decreased with higher collagen loadings. Elongation at break decreased with collagen content. Cell adhesion to the membranes was observed associated with the collagen particles, indicating a lack of cytotoxicity.
Language eng
DOI 10.1016/j.jmbbm.2015.04.005
Field of Research 091209 Polymers and Plastics
Socio Economic Objective 860606 Plastics in Primary Forms
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075561

Document type: Journal Article
Collection: Institute for Frontier Materials
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Created: Wed, 16 Sep 2015, 15:14:40 EST

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