Synthesis and comparative physical-chemical characterisation of neutral and cationic amphiphiles using RP-HPLC

Squire, Jennifer S., Henderson, Luke C. and Conlan, Xavier A. 2013, Synthesis and comparative physical-chemical characterisation of neutral and cationic amphiphiles using RP-HPLC, Current analytical chemistry, vol. 9, no. 4, pp. 653-658.

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Title Synthesis and comparative physical-chemical characterisation of neutral and cationic amphiphiles using RP-HPLC
Author(s) Squire, Jennifer S.
Henderson, Luke C.ORCID iD for Henderson, Luke C. orcid.org/0000-0002-4244-2056
Conlan, Xavier A.ORCID iD for Conlan, Xavier A. orcid.org/0000-0003-0829-0551
Journal name Current analytical chemistry
Volume number 9
Issue number 4
Start page 653
End page 658
Total pages 6
Publisher Bentham Science Publishers
Place of publication Amsterdam, The Netherlands
Publication date 2013
ISSN 1573-4110
Keyword(s) Amphiphiles
Capacity factor
Cationic lipid
High performance liquid chromatography
Lipophilicity
Science & Technology
Physical Sciences
Chemistry, Analytical
Chemistry
PERFORMANCE LIQUID-CHROMATOGRAPHY
RETENTION
Summary A series of norbornane containing amphiphiles was synthesized, their lipophilicity corresponding to neutral and cationic forms was then investigated using reverse phase HPLC (High Performance Liquid Chromatography). This series of amphiphiles incorporated varied lipophilic chain length and also varied distances between the polar/cationic head group from the norbornane scaffold. Our investigation included studying the impact of the stationary phase as a replication of a membrane for both cationic and neutral amphiphiles. The choice of stationary phase was shown to be a very important consideration for this type of measurement. In this connection, C18, Cyano and Polar columns were all investigated, the cyano column was observed to be the optimal stationary phase for the comparison of both charged and neutral amphiphiles.
Language eng
Field of Research 030101 Analytical Spectrometry
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075585

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