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MicroRNAs: association with radioresistant and potential uses of natural remedies as green gene therapeutic approaches

Jothy, Subramanion L., Chen, Yeng, Vijayarathna, Soundararajan, Kanwar, Jagat R. and Sasidharan, Sreenivasan 2015, MicroRNAs: association with radioresistant and potential uses of natural remedies as green gene therapeutic approaches, Current gene therapy, vol. 15, no. 1, pp. 15-20, doi: 10.2174/1566523215666141205104117.

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Title MicroRNAs: association with radioresistant and potential uses of natural remedies as green gene therapeutic approaches
Author(s) Jothy, Subramanion L.
Chen, Yeng
Vijayarathna, Soundararajan
Kanwar, Jagat R.
Sasidharan, Sreenivasan
Journal name Current gene therapy
Volume number 15
Issue number 1
Start page 15
End page 20
Total pages 6
Publisher Bentham Science Publishers
Place of publication Beijing, China
Publication date 2015
ISSN 1875-5631
Keyword(s) cell line, tumor
genetic therapy
humans
MicroRNAs
neoplasms
phytochemicals
radiation-protective agents
radiotherapy
Summary Radiotherapy plays an essential primary role in cancer patients. Regardless of its significant advances in treatment options, tumor recurrence and radio-resistance in cancer cells still occur in a high percentage of patients. Furthermore, the over expression of miRNAs accompanies the development of radio-resistant cancer cells. Consequently, miRNAs might serve as therapeutic targets for the treatment of radio-resistance in cancer cells. The findings of the current research also signify that the use of a natural anti-miRNA substance could inhibit specific miRNAs, and, concurrently, these natural remedies could exhibit radioprotective activity against the healthy cells during radiotherapy. Therefore, in this review, we have reported the association of miRNAs with radio-resistance and the potential uses of natural remedies as green gene therapeutic approaches, as well as radioprotectors against the adverse effects of irradiation on healthy cells during radiotherapy.
Language eng
DOI 10.2174/1566523215666141205104117
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075691

Document type: Journal Article
Collection: School of Medicine
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