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Nanoformulated mutant SurR9-C84A: a possible key for alzheimer's and its associated inflammation

Sriramoju, Bhasker, Kanwar, Rupinder K. and Kanwar, Jagat R. 2015, Nanoformulated mutant SurR9-C84A: a possible key for alzheimer's and its associated inflammation, Pharmaceutical research, vol. 32, no. 8, pp. 2787-2797, doi: 10.1007/s11095-015-1664-8.

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Title Nanoformulated mutant SurR9-C84A: a possible key for alzheimer's and its associated inflammation
Author(s) Sriramoju, Bhasker
Kanwar, Rupinder K.
Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R. orcid.org/0000-0003-3728-9568
Journal name Pharmaceutical research
Volume number 32
Issue number 8
Start page 2787
End page 2797
Total pages 11
Publisher Springer
Place of publication New York, N. Y.
Publication date 2015-08
ISSN 1573-904X
Keyword(s) Science & Technology
Physical Sciences
Life Sciences & Biomedicine
Chemistry, Multidisciplinary
Pharmacology & Pharmacy
Chemistry
Alzheimer's disease
inflammation
neurodegeneration
SurR9-C84A and beta-amyloid
ACTIVATED PROTEIN-KINASE
PARKINSONS-DISEASE
NEUROBLASTOMA-CELLS
IN-VIVO
ASTROCYTES
EXPRESSION
APOPTOSIS
BRAIN
INHIBITION
BCL-2
Summary PURPOSE: Alzheimer's disease (AD) is one of the untreatable neurodegenerative diseases characterised by the pathologic amyloid plaque deposition and inflammation. The aim of this study is to evaluate the neuroprotective effects of nanoformulated SurR9-C84A, a survivin mutant belonging to the inhibitors of the apoptosis (IAP) protein family. The effect of SurR9-C84A was studied against the β-amyloid toxicity and various inflammatory insults in the differentiated SK-N-SH neurons. METHOD: SurR9-C84A loaded poly(lactic-co-glycolic acid) nanoparticles were prepared following the modified double emulsion technique. The neuroprotective effect of SurR9-C84A was evaluated against the amyloid-β (Aβ) peptide fragment, N-methyl-D-aspartate (NMDA) toxicity and the inflammatory assaults. To mimic the in vivo situation, a co-culture of neurons and microglia was also studied to validate these results. RESULTS: SurR9-C84A treatments showed improved neuronal health following Aβ, and NMDA toxicity in addition to inflammatory insults induced in mono and co-cultures. The neuroprotective effect was evident with the reduced neuronal death, accelerated expression of neuronal integrity markers (neurofilaments, beta-tubulin III etc.,) and the neuroprotective ERK/MAPK signalling. CONCLUSION: The current results demonstrated that the SurR9-C84A nanoformulation was very effective in rescuing the neurons and holds a potential future application against AD.
Language eng
DOI 10.1007/s11095-015-1664-8
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920112 Neurodegenerative Disorders Related to Ageing
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075692

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 15 Oct 2015, 14:50:56 EST

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