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Multifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions

Kanwar, Jagat R., Roy, Kislay, Patel, Yogesh, Zhou, Shu-Feng, Singh, Manju Rawat, Singh, Deependra, Nasir, Muhammad, Sehgal, Rakesh, Sehgal, Alka, Singh, Ram Sarup, Garg, Sanjay and Kanwar, Rupinder K. 2015, Multifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions, Molecules, vol. 20, no. 6, pp. 9703-9731, doi: 10.3390/molecules20069703.

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Title Multifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions
Author(s) Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R. orcid.org/0000-0003-3728-9568
Roy, Kislay
Patel, Yogesh
Zhou, Shu-Feng
Singh, Manju Rawat
Singh, Deependra
Nasir, Muhammad
Sehgal, Rakesh
Sehgal, Alka
Singh, Ram Sarup
Garg, Sanjay
Kanwar, Rupinder K.
Journal name Molecules
Volume number 20
Issue number 6
Start page 9703
End page 9731
Total pages 29
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2015-05-26
ISSN 1420-3049
Keyword(s) bovine
camel
cancer
immunity
lactoferrin
nanoparticles
Animals
Anti-Infective Agents
Anti-Inflammatory Agents
Antineoplastic Agents
Camelus
Cattle
Clinical Trials as Topic
Goats
Humans
Immunity, Innate
Inflammation
Iron
Iron Chelating Agents
Neoplasms
Neutrophils
Summary Lactoferrin (Lf), an iron-binding protein from the transferrin family has been reported to have numerous functions. Even though Lf was first isolated from milk, it is also found in most exocrine secretions and in the secondary granules of neutrophils. Antimicrobial and anti-inflammatory activity reports on lactoferrin identified its significance in host defense against infection and extreme inflammation. Anticarcinogenic reports on lactoferrin make this protein even more valuable. This review is focused on the structural configuration of iron-containing and iron-free forms of lactoferrin obtained from different sources such as goat, camel and bovine. Apart for emphasizing on the specific beneficial properties of lactoferrin from each of these sources, the general antimicrobial, immunomodulatory and anticancer activities of lactoferrin are discussed here. Implementation of nanomedicinial strategies that enhance the bioactive function of lactoferrin are also discussed, along with information on lactoferrin in clinical trials.
Language eng
DOI 10.3390/molecules20069703
Field of Research 0305 Organic Chemistry
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075694

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.