Investigating the changes in heart rate asymmetry (HRA) with perturbation of parasympathetic nervous system

Karmakar, Chandan, Khandoker, Ahsan and Palaniswami, Marimuthu 2012, Investigating the changes in heart rate asymmetry (HRA) with perturbation of parasympathetic nervous system, Australasian physical and engineering sciences in medicine, vol. 35, no. 4, pp. 465-474, doi: 10.1007/s13246-012-0173-x.

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Title Investigating the changes in heart rate asymmetry (HRA) with perturbation of parasympathetic nervous system
Author(s) Karmakar, ChandanORCID iD for Karmakar, Chandan
Khandoker, Ahsan
Palaniswami, Marimuthu
Journal name Australasian physical and engineering sciences in medicine
Volume number 35
Issue number 4
Start page 465
End page 474
Total pages 10
Publisher Springer
Place of publication Amsterdam, The Netherlands
Publication date 2012-12
ISSN 0158-9938
Keyword(s) Heart rate asymmetry (HRA)
Heart rate variability (HRV)
Poincare´ plot
Parasympathetic activity
Summary The heart rate asymmetry (HRA) is a disproportionate distribution of heart rate signal. The current study was designed to assess the changes in HRA in experimental conditions using Poincaré plot during parasympathetic blockade (atropine infusion) and parasympathetic enhancement (scopolamine administration). After atropine infusion, the heart rate variability in 5 out of 8 subjects was found asymmetric. In contrast, all 8 subjects were found to be asymmetric during scopolamine administration. The physiological relevance of HRA was demonstrated by showing correlation with standard frequency domain parameters during all phases of the experiment. The deviation of asymmetry index (GI ( p )) from symmetric range was further analyzed, which was maximum during scopolamine administration and minimum during atropine infusion. These findings suggest that parasympathetic block reduces the prevalence of HRA, and has significant correlation of GI ( p ) with frequency domain features of HRV analysis.
Language eng
DOI 10.1007/s13246-012-0173-x
Field of Research 090609 Signal Processing
080109 Pattern Recognition and Data Mining
Socio Economic Objective 920203 Diagnostic Methods
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Australasian College of Physical Scientists and Engineers in Medicine
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