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The anti-inflammatory and pharmacological actions of oleocanthal, a phenolic contained in extra virgin olive oil

Lucas, Lisa, Cicerale, Sara and Keast, Russell 2011, The anti-inflammatory and pharmacological actions of oleocanthal, a phenolic contained in extra virgin olive oil, Anti-inflammatory and anti-allergy agents in medicinal chemistry, vol. 10, no. 6, pp. 399-406, doi: 10.2174/1871523011109060399.

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Title The anti-inflammatory and pharmacological actions of oleocanthal, a phenolic contained in extra virgin olive oil
Author(s) Lucas, Lisa
Cicerale, SaraORCID iD for Cicerale, Sara orcid.org/0000-0002-1100-0423
Keast, RussellORCID iD for Keast, Russell orcid.org/0000-0003-2147-7687
Journal name Anti-inflammatory and anti-allergy agents in medicinal chemistry
Volume number 10
Issue number 6
Start page 399
End page 406
Total pages 8
Publisher Bentham Science Publishers
Place of publication Mersin, Turkey
Publication date 2011
ISSN 1871-5230
1875-614X
Keyword(s) chronic disease
extra virgin olive oil
inflammation
Mediterranean diet
oleocanthal
phenolic compound
Summary Extra virgin olive oil (EVOO) is consumed as part of the health promoting Mediterranean diet and contains several phenolic compounds that are responsible for the unique and distinctive flavour of EVOO. The phenolic fraction of EVOO also imparts many beneficial effects on human health. Oleocanthal is an EVOO phenolic that shares a unique perceptual quality with the non-steroidal anti-inflammatory drug (NSAID) ibuprofen and also mimics the anti-inflammatory actions of this drug. Oleocanthal has therefore been deemed a naturally occurring NSAID because of its demonstrated attenuation of cyclooxygenase (COX) activity in a dose dependent manner. New and emerging research has reported that oleocanthal also acts on inflammatory markers associated with neurodegenerative disease, joint degenerative disease, and cancer. This review will give an up-to-date summary of the history of oleocanthal and the current evidence establishing oleocanthal as a potent natural anti-inflammatory agent.
Language eng
DOI 10.2174/1871523011109060399
Field of Research 110399 Clinical Sciences not elsewhere classified
030499 Medicinal and Biomolecular Chemistry not elsewhere classified
0304 Medicinal And Biomolecular Chemistry
1107 Immunology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075780

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