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The control of epidermal growth factor grafted on mesoporous silica nanoparticles for targeted delivery

She, Xiaodong, Chen, Lijue, Velleman, Leonora, Li, Chengpeng, He, Canzhong, Denman, John, Wang, Tao, Shigdar, Sarah, Duan,Wei and Kong, Lingxue 2015, The control of epidermal growth factor grafted on mesoporous silica nanoparticles for targeted delivery, Journal of materials chemistry B, vol. 3, no. 29, pp. 6094-6104, doi: 10.1039/c5tb00790a.

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Title The control of epidermal growth factor grafted on mesoporous silica nanoparticles for targeted delivery
Author(s) She, Xiaodong
Chen, Lijue
Velleman, Leonora
Li, Chengpeng
He, Canzhong
Denman, John
Wang, Tao
Shigdar, SarahORCID iD for Shigdar, Sarah
Duan,WeiORCID iD for Duan,Wei
Kong, LingxueORCID iD for Kong, Lingxue
Journal name Journal of materials chemistry B
Volume number 3
Issue number 29
Start page 6094
End page 6104
Total pages 11
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2015-08-07
ISSN 2050-7518
Keyword(s) Science & Technology
Materials Science, Biomaterials
Materials Science
Summary The performance of biomaterials in a biological environment is largely influenced by the surface properties of the biomaterials. In particular, grafted targeting ligands significantly impact the subsequent cellular interactions. The utilisation of a grafted epidermal growth factor (EGF) is effective for targeted delivery of drugs to tumours, but the amount of these biological attachments cannot be easily quantified as most characterization methods could not detect the extremely low amount of EGF ligands grafted on the surface of nanoparticles. In this study, hollow mesoporous silica nanoparticles (HMSNs) were functionalized with amine groups to conjugate with EGFs via carbodiimide chemistry. Time of flight secondary ion mass spectrometry (ToF-SIMS), a very surface specific technique (penetration depth <1.5 nm), was employed to study the binding efficiency of the EGF to the nanoparticles. Principal component analysis (PCA) was implemented to track the relative surface concentrations of EGFs on HMSNs. It was found that ToF-SIMS combined with the PCA technique is an effective method to evaluate the immobilization efficiency of EGFs. Based on this useful technique, the quantity and density of the EGF attachments that grafted on nanoparticles can be effectively controlled by varying the EGF concentration at grafting stages. Cell experiments demonstrated that the targeting performance of EGFR positive cells was affected by the number of EGFs attached on HMSNs.
Language eng
DOI 10.1039/c5tb00790a
Field of Research 030302 Nanochemistry and Supramolecular Chemistry
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Royal Society of Chemistry
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Document type: Journal Article
Collections: School of Medicine
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Created: Wed, 16 Sep 2015, 15:39:48 EST

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