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Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon

Li, Puwang, Yang, Ziming, Wang, Yichao, Peng, Zheng, Li, Sidong, Kong, Lingxue and Wang, Qinghuang 2015, Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon, Journal of microencapsulation, vol. 32, no. 1, pp. 40-45, doi: 10.3109/02652048.2014.944947.

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Title Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon
Author(s) Li, Puwang
Yang, Ziming
Wang, Yichao
Peng, Zheng
Li, Sidong
Kong, LingxueORCID iD for Kong, Lingxue orcid.org/0000-0001-6219-3897
Wang, Qinghuang
Journal name Journal of microencapsulation
Volume number 32
Issue number 1
Start page 40
End page 45
Total pages 6
Publisher Taylor and Francis
Place of publication London, Eng
Publication date 2015
ISSN 1464-5246
Keyword(s) 5-Fluorourical
colon cancer
drug delivery
leucovorin
microencapsulation
Science & Technology
Physical Sciences
Technology
Life Sciences & Biomedicine
Chemistry, Applied
Engineering, Chemical
Pharmacology & Pharmacy
Chemistry
Engineering
MULTIPARTICULATE SYSTEM
IN-VITRO
GUAR GUM
DESIGN
MICROSPHERES
5-FLUOROURACIL
POLYSACCHARIDES
Summary Folate-chitosan nanoparticles, co-loaded with 5-fluourouacil (5-FU) and leucovorin (LV) and prepared by ionic gelation technology were physically microencapsulated by enteric polymer using a solvent evaporation method. Average particle size of the microencapsulated particles was in the range of 15 to 35 µm. High drug encapsulation efficiency was obtained for both 5-FU and LV in the microencapsulated particles. Both drugs were in amorphous state in the microencapsulated particles. By enteric coating, excellent pH-dependent release profile was achieved and no drug release was observed in simulated gastric and intestinal fluids. However, when the pH value reached the soluble threshold of Eudragit S-100, a constant and slow drug release was observed. The results indicated that these microencapsulated particles are a promising vehicle for selectively targeting drugs to colon in the chemotherapy of colon cancer.
Language eng
DOI 10.3109/02652048.2014.944947
Field of Research 1115 Pharmacology And Pharmaceutical Sciences
090301 Biomaterials
Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Taylor and Francis
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075880

Document type: Journal Article
Collection: Institute for Frontier Materials
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