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Disc herniations in astronauts: What causes them, and what does it tell us about herniation on earth?

Belavy, Daniel L., Adams, Michael, Brisby, Helena, Cagnie, Barbara, Danneels, Lieven, Fairbank, Jeremy, Hargens, Alan R., Judex, Stefan, Scheuring, Richard A., Sovelius, Roope, Urban, Jill, van Dieën, Jaap H. and Wilke, Hans-Joachim 2016, Disc herniations in astronauts: What causes them, and what does it tell us about herniation on earth?, European spine journal, vol. 25, no. 1, pp. 144-154.

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Title Disc herniations in astronauts: What causes them, and what does it tell us about herniation on earth?
Author(s) Belavy, Daniel L.ORCID iD for Belavy, Daniel L. orcid.org/0000-0002-9307-832X
Adams, Michael
Brisby, Helena
Cagnie, Barbara
Danneels, Lieven
Fairbank, Jeremy
Hargens, Alan R.
Judex, Stefan
Scheuring, Richard A.
Sovelius, Roope
Urban, Jill
van Dieën, Jaap H.
Wilke, Hans-Joachim
Journal name European spine journal
Volume number 25
Issue number 1
Start page 144
End page 154
Total pages 11
Publisher Springer
Place of publication Berlin, Germany
Publication date 2016-01
ISSN 1432-0932
Keyword(s) Atrophy
Back pain
Bed rest
Inactivity
Muscle
Prolapse
Summary PURPOSE: Recent work showed an increased risk of cervical and lumbar intervertebral disc (IVD) herniations in astronauts. The European Space Agency asked the authors to advise on the underlying pathophysiology of this increased risk, to identify predisposing factors and possible interventions and to suggest research priorities. METHODS: The authors performed a narrative literature review of the possible mechanisms, and conducted a survey within the team to prioritize research and prevention approaches. RESULTS AND CONCLUSIONS: Based on literature review the most likely cause for lumbar IVD herniations was concluded to be swelling of the IVD in the unloaded condition during spaceflight. For the cervical IVDs, the knowledge base is too limited to postulate a likely mechanism or recommend approaches for prevention. Basic research on the impact of (un)loading on the cervical IVD and translational research is needed. The highest priority prevention approach for the lumbar spine was post-flight care avoiding activities involving spinal flexion, followed by passive spinal loading in spaceflight and exercises to reduce IVD hyper-hydration post-flight.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30075941

Document type: Journal Article
Collection: Centre for Physical Activity and Nutrition Research
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Created: Thu, 20 Aug 2015, 15:16:45 EST

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