Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest

Belavý, Daniel L., Baecker, Natalie, Armbrecht, Gabriele, Beller, Gisela, Buehlmeier, Judith, Frings-Meuthen, Petra, Rittweger, Jorn, Roth, Heinz J., Heer, Martina and Felsenberg, Dieter 2016, Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest, Journal of bone and mineral metabolism, vol. 34, no. 3, pp. 354-365, doi: 10.1007/s00774-015-0681-3.

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Title Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest
Author(s) Belavý, Daniel L.ORCID iD for Belavý, Daniel L.
Baecker, Natalie
Armbrecht, Gabriele
Beller, Gisela
Buehlmeier, Judith
Frings-Meuthen, Petra
Rittweger, Jorn
Roth, Heinz J.
Heer, Martina
Felsenberg, Dieter
Journal name Journal of bone and mineral metabolism
Volume number 34
Issue number 3
Start page 354
End page 365
Total pages 12
Publisher Springer
Place of publication Tokyo, Japan
Publication date 2016-05
ISSN 0914-8779
Keyword(s) bone mineral density
Summary The impact of effective exercise against bone loss during experimental bed rest appears to be associated with increases in bone formation rather than reductions of bone resorption. Sclerostin and dickkopf-1 are important inhibitors of osteoblast activity. We hypothesized that exercise in bed rest would prevent increases in sclerostin and dickkopf-1. Twenty-four male subjects performed resistive vibration exercise (RVE; n = 7), resistive exercise only (RE; n = 8), or no exercise (control n = 9) during 60 days of bed rest (2nd Berlin BedRest Study). We measured serum levels of BAP, CTX-I, iPTH, calcium, sclerostin, and dickkopf-1 at 16 time-points during and up to 1 year after bed rest. In inactive control, after an initial increase in both BAP and CTX-I, sclerostin increased. BAP then returned to baseline levels, and CTX-I continued to increase. In RVE and RE, BAP increased more than control in bed rest (p ≤ 0.029). Increases of CTX-I in RE and RVE did not differ significantly to inactive control. RE may have attenuated increases in sclerostin and dickkopf-1, but this was not statistically significant. In RVE there was no evidence for any impact on sclerostin and dickkopf-1 changes. Long-term recovery of bone was also measured and 6-24 months after bed rest, and proximal femur bone mineral content was still greater in RVE than control (p = 0.01). The results, while showing that exercise against bone loss in experimental bed rest results in greater bone formation, could not provide evidence that exercise impeded the rise in serum sclerostin and dickkopf-1 levels.
Language eng
DOI 10.1007/s00774-015-0681-3
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Japanese Society for Bone and Mineral Research and Springer Japan
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