Accelerated stem cell attachment to ultrafine grained titanium

Estrin, Yuri, Ivanova, Elena P., Michalska, Anna, Truong, Vi Khanh, Lapovok, Rimma and Boyd, Richard 2011, Accelerated stem cell attachment to ultrafine grained titanium, Acta biomaterialia, vol. 7, no. 2, pp. 900-906, doi: 10.1016/j.actbio.2010.09.033.

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Title Accelerated stem cell attachment to ultrafine grained titanium
Author(s) Estrin, Yuri
Ivanova, Elena P.
Michalska, Anna
Truong, Vi Khanh
Lapovok, Rimma
Boyd, Richard
Journal name Acta biomaterialia
Volume number 7
Issue number 2
Start page 900
End page 906
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2011-02
ISSN 1878-7568
Keyword(s) mesenchymal stem cell
cell adhesion
cell spreading
Summary Commercial purity titanium with an average grain size in the low sub-micron range was produced by equal channel angular pressing (ECAP). Attachment of human bone marrow-derived mesenchymal stem cells (hMSCs) to the surface of conventional coarse grained and ECAP-modified titanium was studied. It was demonstrated that the attachment and spreading of hMSCs in the initial stages (up to 24h) of culture was enhanced by grain refinement. Surface characterization by a range of techniques showed that the main factor responsible for the observed acceleration of hMSC attachment and spreading on titanium due to grain refinement in the bulk is the attendant changes in surface topography on the nanoscale. These results indicate that, in addition to its superior mechanical properties, ECAP-modified titanium possesses improved biocompatibility, which makes it to a potent candidate for applications in medical implants.
Language eng
DOI 10.1016/j.actbio.2010.09.033
Field of Research 091207 Metals and Alloy Materials
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2010, Acta Materialia
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Document type: Journal Article
Collection: Institute for Frontier Materials
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