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Determination of a,4-dihydroxy-3-methoxybenzeneacetic acid (vanilmandelic acid) by flow injection analysis coupled with luminol-hexacyanoferrate(III) chemiluminescence detection

Barnett, Neil W., Francis, Paul, Lewis, Simon W, and Lim, Kieran 1999, Determination of a,4-dihydroxy-3-methoxybenzeneacetic acid (vanilmandelic acid) by flow injection analysis coupled with luminol-hexacyanoferrate(III) chemiluminescence detection, Analytical communications, vol. 36, no. 4, pp. 131-134.

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Title Determination of a,4-dihydroxy-3-methoxybenzeneacetic acid (vanilmandelic acid) by flow injection analysis coupled with luminol-hexacyanoferrate(III) chemiluminescence detection
Author(s) Barnett, Neil W.
Francis, PaulORCID iD for Francis, Paul orcid.org/0000-0003-4165-6922
Lewis, Simon W,
Lim, KieranORCID iD for Lim, Kieran orcid.org/0000-0001-5355-8030
Journal name Analytical communications
Volume number 36
Issue number 4
Start page 131
End page 134
Total pages 4
Publisher Royal Society of Chemistry
Place of publication London, Eng.
Publication date 1999
ISSN 1359-7337
Summary A simple and robust method for the determination of the clinically significant molecule vanilmandelic acid (alpha,4-dihydroxy-3-methoxybenzeneacetic acid, 4-hydroxy-3-methoxymandelic acid) using now injection analysis with chemiluminescence detection is described. This compound was found to enhance the chemiluminescence from the reaction of luminol with hexacyanoferrate(III) in a basic medium. The calibration function obtained over the range from 2.5 x 10(-8) to 1.0 x 10(-6) mol dm(-3) approximated to linearity (r(2) = 0.9995) with the equation of best fit of y = 1.72 x 10(8) x + 36.9, where y is the integrated signal (V s) and x is the concentration (mol dm(-3)). Precision (as measured by relative standard deviation) was 2.6% for 5 replicate analyses of a standard (2.5 x 10(-7) mol dm(-3)) and the limit of detection (3 sigma) was 2 x 10(-8) mol dm(-3), Preliminary investigations revealed that the structurally similar homovanillic acid inhibits the emission of chemiluminescence from the luminol-hexacyanoferrate(III) reaction and that the kinetics of light emission were different from those of the vanilmandelic acid enhanced reaction.
Language eng
Field of Research 030103 Flow Analysis
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©1999, The Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30076136

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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