Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines

Macreadie, Ian G., Avery, Thomas D., Robinson, Tony V., Macreadie, Peter, Barraclough, Miles, Taylor, Dennis K. and Tiekink, Edward R.T. 2008, Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines, Tetrahedron, vol. 64, no. 7, pp. 1225-1232, doi: 10.1016/j.tet.2007.11.071.

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Title Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines
Author(s) Macreadie, Ian G.
Avery, Thomas D.
Robinson, Tony V.
Macreadie, PeterORCID iD for Macreadie, Peter orcid.org/0000-0001-7362-0882
Barraclough, Miles
Taylor, Dennis K.
Tiekink, Edward R.T.
Journal name Tetrahedron
Volume number 64
Issue number 7
Start page 1225
End page 1232
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2008-02-11
ISSN 0040-4020
Summary In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure-activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and their parent 1,2-dioxines 1 were assessed primarily against the pathogenic yeast, Candida albicans, with haemolytic activity of selected examples also reported.
Language eng
DOI 10.1016/j.tet.2007.11.071
Field of Research 030503 Organic Chemical Synthesis
Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2008, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30076242

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