Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines

Macreadie, Ian G., Avery, Thomas D., Robinson, Tony V., Macreadie, Peter, Barraclough, Miles, Taylor, Dennis K. and Tiekink, Edward R.T. 2008, Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines, Tetrahedron, vol. 64, no. 7, pp. 1225-1232, doi: 10.1016/j.tet.2007.11.071.

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Title Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines
Author(s) Macreadie, Ian G.
Avery, Thomas D.
Robinson, Tony V.
Macreadie, PeterORCID iD for Macreadie, Peter
Barraclough, Miles
Taylor, Dennis K.
Tiekink, Edward R.T.
Journal name Tetrahedron
Volume number 64
Issue number 7
Start page 1225
End page 1232
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2008-02-11
ISSN 0040-4020
Summary In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure-activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and their parent 1,2-dioxines 1 were assessed primarily against the pathogenic yeast, Candida albicans, with haemolytic activity of selected examples also reported.
Language eng
DOI 10.1016/j.tet.2007.11.071
Field of Research 030503 Organic Chemical Synthesis
Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2008, Elsevier
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