Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response

Caine, Jo, Sankovich, Sonia, Antony, Helma, Waddington, Lynne, Macreadie, Peter, Varghese, Jose and Macreadie, Ian 2007, Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response, FEMS yeast research, vol. 7, no. 8, pp. 1230-1236, doi: 10.1111/j.1567-1364.2007.00285.x.

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Title Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response
Formatted title Alzheimer’s Aβ fused to green fluorescent protein induces growth stress and a heat shock response
Author(s) Caine, Jo
Sankovich, Sonia
Antony, Helma
Waddington, Lynne
Macreadie, PeterORCID iD for Macreadie, Peter orcid.org/0000-0001-7362-0882
Varghese, Jose
Macreadie, Ian
Journal name FEMS yeast research
Volume number 7
Issue number 8
Start page 1230
End page 1236
Total pages 7
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2007-12
ISSN 1567-1356
Keyword(s) β amyloid

Alzheimer's disease
Heat shock response
Protein misfolding
Reactive oxygen species
Summary The 42 amino acid Alzheimer's Aβ peptide is involved in the progression of Alzheimer's disease. Here we describe the effects of intracellular Aβ, produced through its attachment to either end of a green fluorescent protein, in yeast. Cells producing Aβ exhibited a lower growth yield and a heat shock response, showing that Aβ fusions promote stress in cells and supporting the notion that intracellular Aβ is a toxic molecule. These studies have relevance in understanding the role of Aβ in the death of neuronal cells, and indicate that yeast may be a new tractable model system for the screening for inhibitors of the stress caused by Aβ.
Language eng
DOI 10.1111/j.1567-1364.2007.00285.x
Field of Research 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics)
Socio Economic Objective 920112 Neurodegenerative Disorders Related to Ageing
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2007, Oxford University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30076243

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