Design of endoperoxides with anti-Candida activity

Avery, Thomas D., Macreadie, Peter I., Greatrex, Ben W., Robinson, Tony V., Taylor, Dennis K. and Macreadie, Ian G. 2007, Design of endoperoxides with anti-Candida activity, Bioorganic & medicinal chemistry, vol. 15, no. 1, pp. 36-42, doi: 10.1016/j.bmc.2006.10.021.

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Title Design of endoperoxides with anti-Candida activity
Author(s) Avery, Thomas D.
Macreadie, Peter I.ORCID iD for Macreadie, Peter I.
Greatrex, Ben W.
Robinson, Tony V.
Taylor, Dennis K.
Macreadie, Ian G.
Journal name Bioorganic & medicinal chemistry
Volume number 15
Issue number 1
Start page 36
End page 42
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2007-01-01
ISSN 0968-0896
Keyword(s) Antifungal
Growth inhibition
Hemolytic activity
Summary Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.
Language eng
DOI 10.1016/j.bmc.2006.10.021
Field of Research 030503 Organic Chemical Synthesis
Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, Elsevier
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