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Growth inhibition of Candida species and Aspergillus fumigatus by statins

Macreadie, Ian G., Johnson, Georgia, Schlosser, Tanja and Macreadie, Peter I. 2006, Growth inhibition of Candida species and Aspergillus fumigatus by statins, FEMS microbiology letters, vol. 262, no. 1, pp. 9-13, doi: 10.1111/j.1574-6968.2006.00370.x.

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Title Growth inhibition of Candida species and Aspergillus fumigatus by statins
Author(s) Macreadie, Ian G.
Johnson, Georgia
Schlosser, Tanja
Macreadie, Peter I.ORCID iD for Macreadie, Peter I. orcid.org/0000-0001-7362-0882
Journal name FEMS microbiology letters
Volume number 262
Issue number 1
Start page 9
End page 13
Total pages 5
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2006-09
ISSN 0378-1097
Keyword(s) Antifungal
Atorvastatin
HMG-CoA reductase inhibition
Summary Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins, simvastatin and atorvastatin, on five Candida species and Aspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A. fumigatus with ergosterol or cholesterol in aerobic culture led to substantial recovery from the inhibition by statins, suggesting specificity of statins for the mevalonate synthesis pathway. Our findings suggest that the statins could have utility as antifungal agents and that fungal colonization could be affected in those on statin therapy.
Language eng
DOI 10.1111/j.1574-6968.2006.00370.x
Field of Research 030503 Organic Chemical Synthesis
Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Oxford University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30076249

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