Novel endoperoxides: synthesis and activity against Candida species

Macreadie, Peter, Avery, Thomas, Greatrex, Ben, Taylor, Dennis and Macreadie, Ian 2006, Novel endoperoxides: synthesis and activity against Candida species, Bioorganic & medicinal chemistry letters, vol. 16, no. 4, pp. 920-922, doi: 10.1016/j.bmcl.2005.10.101.

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Title Novel endoperoxides: synthesis and activity against Candida species
Author(s) Macreadie, PeterORCID iD for Macreadie, Peter orcid.org/0000-0001-7362-0882
Avery, Thomas
Greatrex, Ben
Taylor, Dennis
Macreadie, Ian
Journal name Bioorganic & medicinal chemistry letters
Volume number 16
Issue number 4
Start page 920
End page 922
Total pages 3
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2006-02-15
ISSN 0960-894X
Keyword(s) Antifungal
Artemisinin
Endoperoxide
Summary Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic Candida species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against Candida growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.
Language eng
DOI 10.1016/j.bmcl.2005.10.101
Field of Research 030503 Organic Chemical Synthesis
Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2006, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30076250

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