Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years

Kidd, Timothy J., Ramsay, Kay A., Vidmar, Suzanna, Carlin,John B., Bell, Scott C., Wainwright, Claire E., Grimwood, Keith, Francis, Paul W., Dakin,Carolyn, Cheney, Joyce, George, Narelle, Carlin, John B., Robertson, Colin F., Vidmar, Suzanna, Moodie, Marj, Carzino, Rosemary, Carter, Robert, Whitehead, Bruce, Hunter, John, Byrnes, Catherine A., Tiddens, Harm A., Graniel, Karla, Gerbrands, Krista and Mott, Lauren 2015, Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years, Journal of cystic fibrosis, vol. 14, no. 3, pp. 361-369, doi: 10.1016/j.jcf.2014.12.007.

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Title Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years
Author(s) Kidd, Timothy J.
Ramsay, Kay A.
Vidmar, Suzanna
Carlin,John B.
Bell, Scott C.
Wainwright, Claire E.
Grimwood, Keith
Francis, Paul W.
Dakin,Carolyn
Cheney, Joyce
George, Narelle
Carlin, John B.
Robertson, Colin F.
Vidmar, Suzanna
Moodie, Marj
Carzino, Rosemary
Carter, Robert
Whitehead, Bruce
Hunter, John
Byrnes, Catherine A.
Tiddens, Harm A.
Graniel, Karla
Gerbrands, Krista
Mott, Lauren
Journal name Journal of cystic fibrosis
Volume number 14
Issue number 3
Start page 361
End page 369
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-05
ISSN 1873-5010
Keyword(s) Cystic fibrosis
Eradication
Genotyping
Infection
Pseudomonas aeruginosa
ACFBAL Study Investigators
Science & Technology
Life Sciences & Biomedicine
Respiratory System
LAVAGE-DIRECTED THERAPY
CHRONIC LUNG INFECTION
YOUNG-CHILDREN
BRONCHOALVEOLAR LAVAGE
OROPHARYNGEAL CULTURES
ERADICATION THERAPY
DIAGNOSTIC-TOOL
STRAINS
INFANTS
COLONIZATION
Summary BACKGROUND: We describe Pseudomonas aeruginosa acquisitions in children with cystic fibrosis (CF) aged ≤5-years, eradication treatment efficacy, and genotypic relationships between upper and lower airway isolates and strains from non-CF sources. METHODS: Of 168 CF children aged ≤5-years in a bronchoalveolar lavage (BAL)-directed therapy trial, 155 had detailed microbiological results. Overall, 201/271 (74%) P. aeruginosa isolates from BAL and oropharyngeal cultures were available for genotyping, including those collected before and after eradication therapy. RESULTS: Eighty-two (53%) subjects acquired P. aeruginosa, of which most were unique strains. Initial eradication success rate was 90%, but 36 (44%) reacquired P. aeruginosa, with genotypic substitutions more common in BAL (12/14) than oropharyngeal (3/11) cultures. Moreover, oropharyngeal cultures did not predict BAL genotypes reliably. CONCLUSIONS: CF children acquire environmental P. aeruginosa strains frequently. However, discordance between BAL and oropharyngeal strains raises questions over upper airway reservoirs and how to best determine eradication in non-expectorating children.
Language eng
DOI 10.1016/j.jcf.2014.12.007
Field of Research 1103 Clinical Sciences
Socio Economic Objective 920501 Child Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30076615

Document type: Journal Article
Collection: School of Health and Social Development
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