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A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

Fleming, Cassandra L., Ashton, Trent D., Nowell, Cameron, Devlin, Mark, Natoli, Anthony, Schreuders, Jeannette and Pfeffer, Frederick M. 2015, A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging, Chemical communications, vol. 51, no. 37, pp. 7827-7830, doi: 10.1039/c5cc02059j.

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Title A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging
Author(s) Fleming, Cassandra L.
Ashton, Trent D.ORCID iD for Ashton, Trent D. orcid.org/0000-0002-6707-6064
Nowell, Cameron
Devlin, Mark
Natoli, Anthony
Schreuders, Jeannette
Pfeffer, Frederick M.ORCID iD for Pfeffer, Frederick M. orcid.org/0000-0002-5441-6437
Journal name Chemical communications
Volume number 51
Issue number 37
Start page 7827
End page 7830
Total pages 4
Publisher Royal Society of Chemistry
Place of publication London, Eng.
Publication date 2015
ISSN 1364-548X
Keyword(s) Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
CANCER CELLS
CYCLE ARREST
SCRIPTAID
AGENTS
DERIVATIVES
SENSORS
DRUGS
Summary Fluorescence microscopy studies using 4-morpholinoscriptaid (4MS) demonstrated rapid cellular uptake of this scriptaid analogue into the cytoplasm but no nuclear penetration. As 4MS and scriptaid have the same in vitro activity against HDACs and KASUMI-1 cells; 4MS exemplifies a rational approach to subtly modify ‘profluorogenic’ substrates for intracellular studies.
Language eng
DOI 10.1039/c5cc02059j
Field of Research 030401 Biologically Active Molecules
030503 Organic Chemical Synthesis
030302 Nanochemistry and Supramolecular Chemistry
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30076861

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Created: Fri, 27 Nov 2015, 09:15:00 EST

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