Drug loading and release studies for milled silk particles of different sizes

Kazemimostaghim, Mehdi, Rajkhowa, Rangam and Wang, Xungai 2015, Drug loading and release studies for milled silk particles of different sizes, Powder technology, vol. 283, pp. 321-327, doi: 10.1016/j.powtec.2015.05.042.

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Title Drug loading and release studies for milled silk particles of different sizes
Author(s) Kazemimostaghim, Mehdi
Rajkhowa, RangamORCID iD for Rajkhowa, Rangam orcid.org/0000-0002-6811-9126
Wang, XungaiORCID iD for Wang, Xungai orcid.org/0000-0002-3549-6769
Journal name Powder technology
Volume number 283
Start page 321
End page 327
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-10-01
ISSN 0032-5910
1873-328X
Keyword(s) Bead milling
Drug release
Particle size
Silk powder
Summary Milled silk particles with volume median particle size (d(0.5)) of 7 μm and 281 nm as well as silk snippets were used for loading of model drugs Orange G, Azophloxine, Rhodamine B, and Crystal Violet. Loading and release of these chemicals depended on the size of silk particles, pH, and the structure and properties of model drugs. Both types of silk particles reached equilibrium loading in less than 10 min due to high surface area whereas silk fibres needed more than 2-3 days to reach equilibrium, depending on the drug type. The uptake rate in fibres could be improved by increasing temperature. Both fibres and particles could slowly release the drugs over many days at 37 °C without a significant initial burst. As particle size decreased, the amount of model drug release also decreased. The release of drugs by the silk fibres was quicker than the silk particles.
Language eng
DOI 10.1016/j.powtec.2015.05.042
Field of Research 090406 Powder and Particle Technology
091012 Textile Technology
090301 Biomaterials
Socio Economic Objective 860403 Natural Fibres
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30076945

Document type: Journal Article
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