Impact of cannabis use on long-term remission in bipolar I and schizoaffective disorder Kim, Sung-Wan, Dodd, Seetal, Berk, Lesley, Kulkarni, Jayashri, de Castella, Anthony, Fitzgerald, Paul B., Kim, Jae-Min, Yoon, Jin-Sang and Berk, Michael 2015, Impact of cannabis use on long-term remission in bipolar I and schizoaffective disorder, Psychiatry Investigation, vol. 12, no. 3, pp. 349-355, doi: 10.4306/pi.2015.12.3.349. Attached Files Name Description MIMEType Size Downloads dodd-impactofcannabis-2015.pdf Published version application/pdf 2.27MB 14 Title Impact of cannabis use on long-term remission in bipolar I and schizoaffective disorder Author(s) Kim, Sung-Wan Dodd, Seetal orcid.org/0000-0002-7918-4636 Berk, Lesley orcid.org/0000-0002-3677-7503 Kulkarni, Jayashri de Castella, Anthony Fitzgerald, Paul B. Kim, Jae-Min Yoon, Jin-Sang Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Psychiatry Investigation Volume number 12 Issue number 3 Start page 349 End page 355 Total pages 7 Publisher Korean Neuropsychiatric Association Place of publication Seoul, Korea (South) Publication date 2015-07 ISSN 1738-3684 Keyword(s) Bipolar disorder Cannabis Observational study Remission Schizoaffective disorder Substance Science & Technology Life Sciences & Biomedicine Psychiatry EXTREME ATTRIBUTIONS PREDICT 1ST HOSPITALIZATION SUBSTANCE-ABUSE GENDER-DIFFERENCES COOCCURRING ALCOHOL CIGARETTE-SMOKING AUSTRALIAN COHORT PSYCHOTIC MANIA MENTAL-HEALTH RATING-SCALE Summary OBJECTIVE: To investigate the impact of regular cannabis use on long-term remission of mood symptoms in bipolar spectrum disorders. METHODS: The 24-month prospective observational study included patients (n=239) with bipolar I disorder and schizoaffective disorder, bipolar type. Participants were classified as regular cannabis users (three times or more per week) or non-users. The primary outcome measure was the achievement of remission on the evaluations during the 24 months. RESULTS: Of the 234 participants for whom data was available, 25 (10.7%) were regular cannabis users, and the group comprised significantly more males than females. In the total population, cannabis use was significantly associated with decreased likelihood of remission during the 24-month follow-up period. Subgroup analyses showed that cannabis use was significantly associated with lower remission rates on the Hamilton Depression Rating Scale in females (n=139) and patients prescribed mood stabilizers alone (n=151), whereas in males (n=95) and patients prescribed olanzapine and/or a mood stabilizer (n=83), cannabis use was significantly associated with lower remission rates on the Young Mania Rating Scale. Remission rates were lowest in the concurrent cannabis and tobacco smoking group (n=22) followed by the tobacco smoking only group (n=97), and the non-smoker group (n=116). The post-hoc analysis revealed that all remission rates were significantly lower in the concurrent cannabis and the tobacco smoking group compared to the non-smoker group. CONCLUSION: Cannabis use negatively affects the long-term clinical outcome in patients with bipolar spectrum disorders. A comprehensive assessment and integrated management of cannabis use are required to achieve better treatment outcomes for bipolar spectrum disorders. Language eng DOI 10.4306/pi.2015.12.3.349 Field of Research 110999 Neurosciences not elsewhere classified Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2015, Korean Neuropsychiatric Association Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30077020 Document type: Journal Article Collections: School of Medicine Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges     Link to Related Work Impact of cannabis use on long-term remission in bipolar I and schizoaffective disorder (deposited 11-11-2018) Korean Neuropsychiatric Association Publisher (deposited 19-10-2015)   Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. 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