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Impact of cannabis use on long-term remission in bipolar I and schizoaffective disorder

Kim, Sung-Wan, Dodd, Seetal, Berk, Lesley, Kulkarni, Jayashri, de Castella, Anthony, Fitzgerald, Paul B., Kim, Jae-Min, Yoon, Jin-Sang and Berk, Michael 2015, Impact of cannabis use on long-term remission in bipolar I and schizoaffective disorder, Psychiatry Investigation, vol. 12, no. 3, pp. 349-355, doi: 10.4306/pi.2015.12.3.349.

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Title Impact of cannabis use on long-term remission in bipolar I and schizoaffective disorder
Author(s) Kim, Sung-Wan
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Berk, LesleyORCID iD for Berk, Lesley orcid.org/0000-0002-3677-7503
Kulkarni, Jayashri
de Castella, Anthony
Fitzgerald, Paul B.
Kim, Jae-Min
Yoon, Jin-Sang
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Psychiatry Investigation
Volume number 12
Issue number 3
Start page 349
End page 355
Total pages 7
Publisher Korean Neuropsychiatric Association
Place of publication Seoul, Korea (South)
Publication date 2015-07
ISSN 1738-3684
Keyword(s) Bipolar disorder
Cannabis
Observational study
Remission
Schizoaffective disorder
Substance
Science & Technology
Life Sciences & Biomedicine
Psychiatry
EXTREME ATTRIBUTIONS PREDICT
1ST HOSPITALIZATION
SUBSTANCE-ABUSE
GENDER-DIFFERENCES
COOCCURRING ALCOHOL
CIGARETTE-SMOKING
AUSTRALIAN COHORT
PSYCHOTIC MANIA
MENTAL-HEALTH
RATING-SCALE
Summary OBJECTIVE: To investigate the impact of regular cannabis use on long-term remission of mood symptoms in bipolar spectrum disorders. METHODS: The 24-month prospective observational study included patients (n=239) with bipolar I disorder and schizoaffective disorder, bipolar type. Participants were classified as regular cannabis users (three times or more per week) or non-users. The primary outcome measure was the achievement of remission on the evaluations during the 24 months. RESULTS: Of the 234 participants for whom data was available, 25 (10.7%) were regular cannabis users, and the group comprised significantly more males than females. In the total population, cannabis use was significantly associated with decreased likelihood of remission during the 24-month follow-up period. Subgroup analyses showed that cannabis use was significantly associated with lower remission rates on the Hamilton Depression Rating Scale in females (n=139) and patients prescribed mood stabilizers alone (n=151), whereas in males (n=95) and patients prescribed olanzapine and/or a mood stabilizer (n=83), cannabis use was significantly associated with lower remission rates on the Young Mania Rating Scale. Remission rates were lowest in the concurrent cannabis and tobacco smoking group (n=22) followed by the tobacco smoking only group (n=97), and the non-smoker group (n=116). The post-hoc analysis revealed that all remission rates were significantly lower in the concurrent cannabis and the tobacco smoking group compared to the non-smoker group. CONCLUSION: Cannabis use negatively affects the long-term clinical outcome in patients with bipolar spectrum disorders. A comprehensive assessment and integrated management of cannabis use are required to achieve better treatment outcomes for bipolar spectrum disorders.
Language eng
DOI 10.4306/pi.2015.12.3.349
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Korean Neuropsychiatric Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077020

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.