Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

Edwards, Stacey L., Poongavanam, Vasanthanathan, Kanwar, Jagat R., Roy, Kislay, Hillman, Kristine M., Prasad, Neerati, Leth-Larsen, Rikke, Petersen, Michael, Marušič, Maja, Plavec, Janez, Wengel, Jesper and Veedu, Rakesh N. 2015, Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition, Chemical Communications, vol. 51, no. 46, pp. 9499-9502, doi: 10.1039/c5cc02756j.

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Title Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition
Author(s) Edwards, Stacey L.
Poongavanam, Vasanthanathan
Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R. orcid.org/0000-0003-3728-9568
Roy, Kislay
Hillman, Kristine M.
Prasad, Neerati
Leth-Larsen, Rikke
Petersen, Michael
Marušič, Maja
Plavec, Janez
Wengel, Jesper
Veedu, Rakesh N.
Journal name Chemical Communications
Volume number 51
Issue number 46
Start page 9499
End page 9502
Total pages 4
Publisher Royal Society of Chemistry
Place of publication London, Eng.
Publication date 2015
ISSN 1364-548X
Keyword(s) Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
LOCKED NUCLEIC-ACID
CYTO-TOXICITY
GROWTH-FACTOR
THERAPEUTICS
APTAMERS
BEVACIZUMAB
ANALOGS
Summary In this study, we investigated the efficacy of an LNA (locked nucleic acid)-modified DNA aptamer named RNV66 targeting VEGF against various breast cancer cell lines. Our results demonstrate that RNV66 efficiently inhibits breast cancer cell proliferation both in vitro and in vivo. Introduction of LNA nucleotides were crucial for higher efficacy. Furthermore, the binding interaction of RNV66 with VEGF was investigated using molecular dynamic simulations leading to the first computational model of the LNA aptamer-VEGF complex blocking its interaction with VEGF-receptor.
Language eng
DOI 10.1039/c5cc02756j
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077106

Document type: Journal Article
Collection: School of Medicine
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