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Increased premotor cortex activation in high functioning autism during action observation

Perkins, Tom J., Bittar, Richard G., McGillivray, Jane A., Cox, Ivanna I. and Stokes, Mark A. 2015, Increased premotor cortex activation in high functioning autism during action observation, Journal of clinical neuroscience, vol. 22, no. 4, pp. 664-669, doi: 10.1016/j.jocn.2014.10.007.

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Title Increased premotor cortex activation in high functioning autism during action observation
Author(s) Perkins, Tom J.
Bittar, Richard G.
McGillivray, Jane A.ORCID iD for McGillivray, Jane A. orcid.org/0000-0003-2000-6488
Cox, Ivanna I.
Stokes, Mark A.ORCID iD for Stokes, Mark A. orcid.org/0000-0001-6488-4544
Journal name Journal of clinical neuroscience
Volume number 22
Issue number 4
Start page 664
End page 669
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-04
ISSN 1532-2653
Keyword(s) Action observation
Autism spectrum disorders
Mirror neurons
Premotor cortex
fMRI
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
MIRROR-NEURON SYSTEM
ANTERIOR CINGULATE CORTEX
SPECTRUM DISORDERS
MU-SUPPRESSION
MAGNETIC STIMULATION
DORSAL PREMOTOR
MOTOR
IMITATION
CHILDREN
Summary The mirror neuron (MN) hypothesis of autism has received considerable attention, but to date has produced inconsistent findings. Using functional MRI, participants with high functioning autism or Asperger's syndrome were compared to typically developing individuals (n=12 in each group). Participants passively observed hand gestures that included waving, pointing, and grasping. Concerning the MN network, both groups activated similar regions including prefrontal, inferior parietal and superior temporal regions, with the autism group demonstrating significantly greater activation in the dorsal premotor cortex. Concerning other regions, participants with autism demonstrated increased activity in the anterior cingulate and medial frontal gyrus, and reduced activation in calcarine, cuneus, and middle temporal gyrus. These results suggest that during observation of hand gestures, frontal cortex activation is affected in autism, which we suggest may be linked to abnormal functioning of the MN system.
Language eng
DOI 10.1016/j.jocn.2014.10.007
Field of Research 1103 Clinical Sciences
1109 Neurosciences
170205 Neurocognitive Patterns and Neural Networks
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077297

Document type: Journal Article
Collection: School of Psychology
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