Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces
Tang, Zhenghua, Lim, Chang-Keun, Palafox-Hernandez, J. Pablo, Drew, Kurt L. M., Li, Yue, Swihart, Mark T., Prasad, Paras N., Walsh, Tiffany R. and Knecht, Marc R. 2015, Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces, Nanoscale, vol. 7, no. 32, pp. 13638-13645, doi: 10.1039/c5nr02311d.
Attached Files
Name
Description
MIMEType
Size
Downloads
Title
Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces
Bio-molecular non-covalent interactions provide a powerful platform for material-specific self-organization in aqueous media. Here, we introduce a strategy that integrates a synthetic optically-responsive motif with a materials-binding peptide to enable remote actuation. Specifically, we linked a photoswitchable azobenzene moiety to either terminus of a Au-binding peptide. We employed these hybrid molecules as capping agents for synthesis of Au nanoparticles. Integrated experiments and molecular simulations showed that the hybrid molecules maintained both of their functions, i.e. binding to Au and optically-triggered reconfiguration. The azobenzene unit was optically switched reversibly between trans and cis states while adsorbed on the particle surface. Upon switching, the conformation of the peptide component of the molecule also changed. This highlights the interplay between the surface adsorption and conformational switching that will be pivotal to the creation of actuatable nanoparticle bio-interfaces, and paves the way toward multifunctional peptide hybrids that can produce stimuli responsive nanoassemblies.
Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.