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Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces

Tang, Zhenghua, Lim, Chang-Keun, Palafox-Hernandez, J. Pablo, Drew, Kurt L. M., Li, Yue, Swihart, Mark T., Prasad, Paras N., Walsh, Tiffany R. and Knecht, Marc R. 2015, Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces, Nanoscale, vol. 7, no. 32, pp. 13638-13645, doi: 10.1039/c5nr02311d.

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Title Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces
Author(s) Tang, Zhenghua
Lim, Chang-Keun
Palafox-Hernandez, J. Pablo
Drew, Kurt L. M.
Li, Yue
Swihart, Mark T.
Prasad, Paras N.
Walsh, Tiffany R.ORCID iD for Walsh, Tiffany R. orcid.org/0000-0002-0233-9484
Knecht, Marc R.
Journal name Nanoscale
Volume number 7
Issue number 32
Start page 13638
End page 13645
Total pages 8
Publisher Royal Society of Chemistry
Place of publication Cambride, Eng.
Publication date 2015-08-28
ISSN 2040-3364
2040-3372
Summary Bio-molecular non-covalent interactions provide a powerful platform for material-specific self-organization in aqueous media. Here, we introduce a strategy that integrates a synthetic optically-responsive motif with a materials-binding peptide to enable remote actuation. Specifically, we linked a photoswitchable azobenzene moiety to either terminus of a Au-binding peptide. We employed these hybrid molecules as capping agents for synthesis of Au nanoparticles. Integrated experiments and molecular simulations showed that the hybrid molecules maintained both of their functions, i.e. binding to Au and optically-triggered reconfiguration. The azobenzene unit was optically switched reversibly between trans and cis states while adsorbed on the particle surface. Upon switching, the conformation of the peptide component of the molecule also changed. This highlights the interplay between the surface adsorption and conformational switching that will be pivotal to the creation of actuatable nanoparticle bio-interfaces, and paves the way toward multifunctional peptide hybrids that can produce stimuli responsive nanoassemblies.
Language eng
DOI 10.1039/c5nr02311d
Field of Research 030304 Physical Chemistry of Materials
030302 Nanochemistry and Supramolecular Chemistry
030603 Colloid and Surface Chemistry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077448

Document type: Journal Article
Collection: Institute for Frontier Materials
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Created: Mon, 31 Aug 2015, 11:57:58 EST

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