Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces Tang, Zhenghua, Lim, Chang-Keun, Palafox-Hernandez, J. Pablo, Drew, Kurt L. M., Li, Yue, Swihart, Mark T., Prasad, Paras N., Walsh, Tiffany R. and Knecht, Marc R. 2015, Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces, Nanoscale, vol. 7, no. 32, pp. 13638-13645, doi: 10.1039/c5nr02311d. Attached Files Name Description MIMEType Size Downloads Title Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces Author(s) Tang, Zhenghua Lim, Chang-Keun Palafox-Hernandez, J. Pablo Drew, Kurt L. M. Li, Yue Swihart, Mark T. Prasad, Paras N. Walsh, Tiffany R. orcid.org/0000-0002-0233-9484 Knecht, Marc R. Journal name Nanoscale Volume number 7 Issue number 32 Start page 13638 End page 13645 Total pages 8 Publisher Royal Society of Chemistry Place of publication Cambride, Eng. Publication date 2015-08-28 ISSN 2040-3364 2040-3372 Summary Bio-molecular non-covalent interactions provide a powerful platform for material-specific self-organization in aqueous media. Here, we introduce a strategy that integrates a synthetic optically-responsive motif with a materials-binding peptide to enable remote actuation. Specifically, we linked a photoswitchable azobenzene moiety to either terminus of a Au-binding peptide. We employed these hybrid molecules as capping agents for synthesis of Au nanoparticles. Integrated experiments and molecular simulations showed that the hybrid molecules maintained both of their functions, i.e. binding to Au and optically-triggered reconfiguration. The azobenzene unit was optically switched reversibly between trans and cis states while adsorbed on the particle surface. Upon switching, the conformation of the peptide component of the molecule also changed. This highlights the interplay between the surface adsorption and conformational switching that will be pivotal to the creation of actuatable nanoparticle bio-interfaces, and paves the way toward multifunctional peptide hybrids that can produce stimuli responsive nanoassemblies. Language eng DOI 10.1039/c5nr02311d Field of Research 030304 Physical Chemistry of Materials 030302 Nanochemistry and Supramolecular Chemistry 030603 Colloid and Surface Chemistry Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2015, Royal Society of Chemistry Persistent URL http://hdl.handle.net/10536/DRO/DU:30077448 Document type: Journal Article Collections: Institute for Frontier Materials GTP Research Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 31 Aug 2015, 11:55:13 EST Mon, 31 Aug 2015, 11:57:58 EST Tue, 01 Sep 2015, 05:02:03 EST Wed, 14 Oct 2015, 14:32:59 EST Thu, 12 Nov 2015, 05:15:58 EST Wed, 09 Dec 2015, 11:22:29 EST Wed, 09 Dec 2015, 13:01:07 EST Filtered Full Citation counts:   Cited 19 times in TR Web of Science Cited 17 times in Scopus Search Google Scholar Access Statistics: 463 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Mon, 31 Aug 2015, 11:57:58 EST

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