You are not logged in.

DNA polymorphisms at the lipoprotein lipase gene and their association with quantitative variation in plasma high-density lipoproteins and triacylglycerides

Mitchell, R.J., Earl, L., Bray, P., Fripp, Y.J. and Williams, J. 1994, DNA polymorphisms at the lipoprotein lipase gene and their association with quantitative variation in plasma high-density lipoproteins and triacylglycerides, Human biology, vol. 66, no. 3, pp. 383-397.

Attached Files
Name Description MIMEType Size Downloads

Title DNA polymorphisms at the lipoprotein lipase gene and their association with quantitative variation in plasma high-density lipoproteins and triacylglycerides
Author(s) Mitchell, R.J.
Earl, L.
Bray, P.
Fripp, Y.J.
Williams, J.ORCID iD for Williams, J. orcid.org/0000-0002-5633-1592
Journal name Human biology
Volume number 66
Issue number 3
Start page 383
End page 397
Total pages 15
Publisher Wayne State University
Place of publication Detroit, Mi.
Publication date 1994-06
ISSN 0018-7143
Keyword(s) Adult
Aged
Analysis of Variance
DNA
Genetic Variation
Genetics, Population
Genotype
Humans
Hyperlipidemias
Lipoprotein Lipase
Lipoproteins, HDL
Male
Middle Aged
Phenotype
Polymorphism, Genetic
Triglycerides
Summary Lipoprotein lipase (LPL) plays a critical role in the metabolism of lipoproteins because this enzyme hydrolyzes the triacylglycerides in chylomicrons and very low density lipoproteins. This process influences the production of high-density lipoprotein (HDL), which takes up tissue cholesterol for transport to the liver for excretion. Accordingly, LPL qualifies as a candidate gene for understanding lipid metabolic disorders and atherosclerosis. Studies on the relationship between genetic variation at the LPL locus and lipid phenotypes have produced equivocal results to date. To help clarify this issue, we investigated 144 outwardly healthy male Mediterranean migrants (from Italy and Greece), age between 40 and 70 years and resident in Australia, for associations between two common LPL restriction site polymorphisms and the following lipid and lipoprotein phenotypes: total plasma cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triacylglycerides. A series of analysis of variance tests, controlling for age, body mass index, and ethnicity, showed that the HindIII polymorphism at the LPL locus is significantly associated with both triacylglyceride and HDL cholesterol concentrations in this sample. The PvUII polymorphism, however, showed no association with any lipid. Kruskal-Wallis tests confirmed the significance of the associations between the HindIII RFLP and both HDL (p = 0.008) and triacylglycerides (p = 0.03). When the sample was subdivided into subjects who exhibited primary hypertriacylglyceridemia and normolipidemics, a significant difference was observed in the frequency of HindIII (p < 0.05) but not PvuII genotypes. HindIII heterozygotes (H1,H2) were least and H2,H2 individuals were most at risk for triacylglyceridemia. Examination of the normolipidemic sample revealed some evidence for an independent effect of the PvuII polymorphism on both LDL cholesterol and total cholesterol levels.
Language eng
Field of Research 0604 Genetics
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1994, Wayne State University
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077686

Document type: Journal Article
Collections: School of Health and Social Development
Open Access Checking
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 31 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 14 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Mon, 31 Aug 2015, 15:26:58 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.