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Polymorphisms of the gene coding for the cholesteryl ester transfer protein and plasma lipid levels in Italian and Greek migrants to Australia

Mitchell, R.J., Earl, L., Williams, J., Bisucci, T. and Gasiamis, H. 1994, Polymorphisms of the gene coding for the cholesteryl ester transfer protein and plasma lipid levels in Italian and Greek migrants to Australia, Human biology, vol. 66, no. 1, pp. 13-25.

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Title Polymorphisms of the gene coding for the cholesteryl ester transfer protein and plasma lipid levels in Italian and Greek migrants to Australia
Author(s) Mitchell, R.J.
Earl, L.
Williams, J.ORCID iD for Williams, J. orcid.org/0000-0002-5633-1592
Bisucci, T.
Gasiamis, H.
Journal name Human biology
Volume number 66
Issue number 1
Start page 13
End page 25
Total pages 13
Publisher Wayne State University Press
Place of publication Detroit, Mi.
Publication date 1994-02
ISSN 0018-7143
Keyword(s) adult
aged
apolipoproteins
carrier proteins
cholesterol ester transfer proteins
cholesterol, HDL
cholesterol, LDL
emigration and immigration
ethnic groups
female
gene frequency
genotype
glycoproteins
Greece
humans
Italy
male
middle aged
multivariate analysis
phenotype
polymorphism, restriction fragment length
sampling studies
sex characteristics
Victoria
Greeks
Italians
migrants
lipoproteins
association studies
Summary The relation between TaqI restriction fragment length polymorphisms (RFLPs) of the cholesteryl ester transfer protein (CETP) gene and plasma lipid and lipoprotein phenotypes was investigated in a sample of Italian and Greek migrants of both sexes, age 40-69 years. Italians display significantly higher mean triglyceride and lower mean high-density lipoprotein (HDL) cholesterol levels than Greeks. Greek females have significantly higher HDL cholesterol than Greek males, and Italian females have significantly higher low-density lipoprotein (LDL), HDL, and total cholesterol than Italian males. The differences in RFLP allele frequencies between the two ethnic groups and sexes are insignificant. Multivariate analyses show that in the Greek sample the TaqI B RFLP of the CETP gene has a highly significant effect on HDL cholesterol levels regardless of sex and that the TaqI A polymorphism has a significant effect on HDL levels in females but modulates LDL cholesterol concentrations in males. Among Italians, with the sexes considered separately or combined, no such effects of the CETP TaqI polymorphisms are detected. Kruskal-Wallis tests detected associations between the TaqI B polymorphism in all Greek samples but not in the Italian samples. Genotype CETP*B2 exhibits significantly higher HDL cholesterol concentrations than either of the other two TaqI B genotypes, but there is no evidence of a dosage effect of the *B2 allele. These data suggest that associations between the CETP gene and lipid phenotypes can be population specific. Further, they suggest that such associations are mediated in some way by gender.
Language eng
Field of Research 0604 Genetics
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1994, Wayne State University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077689

Document type: Journal Article
Collections: School of Health and Social Development
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