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Two Y-chromosome-specific restriction fragment length polymorphisms (DYS11 and DYZ8) in Italian and Greek migrants to Australia

Mitchell, R.J., Earl, L. and Williams, J.W. 1993, Two Y-chromosome-specific restriction fragment length polymorphisms (DYS11 and DYZ8) in Italian and Greek migrants to Australia, Human biology, vol. 65, no. 3, pp. 387-399.

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Title Two Y-chromosome-specific restriction fragment length polymorphisms (DYS11 and DYZ8) in Italian and Greek migrants to Australia
Author(s) Mitchell, R.J.
Earl, L.
Williams, J.W.ORCID iD for Williams, J.W. orcid.org/0000-0002-5633-1592
Journal name Human biology
Volume number 65
Issue number 3
Start page 387
End page 399
Total pages 13
Publisher Wayne State University Press
Place of publication Detroit, Mi.
Publication date 1993-06
ISSN 0018-7143
Keyword(s) Adult
Aged
Australia
Emigration and Immigration
Gene Frequency
Greece
Humans
Italy
Male
Middle Aged
Polymorphism, Restriction Fragment Length
Restriction Mapping
Y Chromosome
Summary The part of the Y chromosome not involved in recombination has been found to exhibit an extremely low frequency of DNA restriction fragment length polymorphisms (RFLPs) compared with either the X chromosome or autosomes. Also, the few Y-chromosome-specific RFLPs that have been identified have rarely been examined in more than one population. In this study two Y-chromosome-specific RFLPs at loci DYS11 and DYZ8 are examined in Italian and Greek migrants to Australia. The frequency of the rarer (8.5-kb) TaqI allele at DYS11 was 21% in Italians and even greater (34%) in Greeks. There is an inverse relationship between the frequency of the 8.5-kb allele and latitude on the Italian mainland; the regional variation (based on subject's birthplace in Italy) was significant (p < 0.01). The incidence of the 8.5-kb allele in southern Italy may reflect Greek colonization during pre-Roman times when this region was part of Magna Graecia. The frequency of the variant TaqI allele (7, 4 kb) at the DYZ8 locus is much higher in both Greeks and Italians (31% in each) than in Germans (5%), the only previously examined population. DYZ8 shows considerably less variation than DYS11 across the regional divisions of both Greece and Italy. The present findings, when added to the few other data available, indicate that these two Y-chromosome-specific loci are useful markers for investigating population affinities through the paternal line. Also, heterogeneity at these two loci (and added to that at the DYS1 locus) suggests that Mediterranean populations, compared with other groups, exhibit a high level of diversity of Y-chromosome-specific RFLPs.
Language eng
Field of Research 0604 Genetics
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1993, Wayne State University
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077690

Document type: Journal Article
Collections: School of Health and Social Development
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