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Restriction fragment length polymorphism at the CALCA locus identified by the probe pEMBL36 in immigrant populations of Australia

Mitchell, RJ, Earl, L, Howard, J and Williams, JW 1992, Restriction fragment length polymorphism at the CALCA locus identified by the probe pEMBL36 in immigrant populations of Australia, Gene geography, vol. 6, no. 1-2, pp. 47-51.

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Title Restriction fragment length polymorphism at the CALCA locus identified by the probe pEMBL36 in immigrant populations of Australia
Author(s) Mitchell, RJ
Earl, L
Howard, J
Williams, JWORCID iD for Williams, JW orcid.org/0000-0002-5633-1592
Journal name Gene geography
Volume number 6
Issue number 1-2
Start page 47
End page 51
Total pages 5
Publisher Universita degli Studi di Roma
Place of publication [Italy]
Publication date 1992-04
ISSN 0394-249X
Keyword(s) Adult
Aged
Alleles
Asian Continental Ancestry Group
Australia
Calcitonin
Calcitonin Gene-Related Peptide
DNA
Emigration and Immigration
Europe
European Continental Ancestry Group
Gene Frequency
Humans
Italy
Middle Aged
Polymorphism, Restriction Fragment Length
Tasmania
Vietnam
Summary Restriction fragment length polymorphisms detected by the cDNA probe, pEMBL36, at the CALCA locus (calcitonin gene and calcitonin gene related peptide) on TaqI blots were examined in samples from Italian, Greek and Vietnamese migrants to Melbourne, Australia and in a sample of residents from the island of Tasmania, Australia. The frequency of the rarer of the two alleles of this polymorphism, A2 (8.0kb) varied between a low of 6% in Vietnamese to a maximum of 38% in Tasmanians. The frequency range of the A2 allele in European populations, however, was considerably less. Analysis revealed no significant heterogeneity for this polymorphism among either the European or European derived populations, and these combined data exhibited a frequency of 33% for the A2 allele. Though based on a very small Vietnamese sample this study suggests that the A2 allele is less frequent in those of Asian ancestry.
Language eng
Field of Research 111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077692

Document type: Journal Article
Collection: School of Health and Social Development
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