Dual-axis hormonal covariation in adolescence and the moderating influence of prior trauma and aversive maternal parenting

Simmons, Julian G., Byrne, Michelle L., Schwartz, Orli S., Whittle, Sarah L., Sheeber, Lisa, Kaess, Michael, Youssef, George J. and Allen, Nicholas B. 2015, Dual-axis hormonal covariation in adolescence and the moderating influence of prior trauma and aversive maternal parenting, Developmental psychobiology, vol. 57, no. 6, pp. 670-687, doi: 10.1002/dev.21275.

Attached Files
Name Description MIMEType Size Downloads

Title Dual-axis hormonal covariation in adolescence and the moderating influence of prior trauma and aversive maternal parenting
Author(s) Simmons, Julian G.
Byrne, Michelle L.
Schwartz, Orli S.
Whittle, Sarah L.
Sheeber, Lisa
Kaess, Michael
Youssef, George J.ORCID iD for Youssef, George J. orcid.org/0000-0002-6178-4895
Allen, Nicholas B.
Journal name Developmental psychobiology
Volume number 57
Issue number 6
Start page 670
End page 687
Total pages 18
Publisher Wiley
Place of publication London, Eng.
Publication date 2015-09
ISSN 1098-2302
Keyword(s) DHEA
HPA
HPG
adolescence
childhood adversity
cortisol
hormonal coupling
parenting
stress
testosterone
trauma
Summary Adversity early in life can disrupt the functioning of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes and increase risk for negative health outcomes. The interplay between these axes and the environment is complex, and understanding needs to be advanced by the investigation of the multiple hormonal relationships underlying these processes. The current study examined basal hormonal associations between morning levels of cortisol, testosterone, and dehydroepiandrosterone in a cohort of adolescents (mean age 15.56 years). The moderating influence of childhood adversity was also examined, as indexed by self-reported trauma (at mean age 14.91), and observed maternal aggressive parenting (at mean age 12.41). Between-person regressions revealed significant associations between hormones that were moderated by both measures of adversity. In females, all hormones positively covaried, but also interacted with adversity, such that positive covariation was typically only present when levels of trauma and/or aggressive parenting were low. In males, hormonal associations and interactions were less evident; however, interactions were detected for cortisol-testosterone - positively covarying at high levels of aggressive parenting but negatively covarying at low levels - and DHEA-cortisol - similarly positively covarying at high levels of parental aggression. These results demonstrate associations between adrenal and gonadal hormones and the moderating role of adversity, which is likely driven by feedback mechanisms, or cross-talk, between the axes. These findings suggest that hormonal changes may be the pathway through which early life adversity alters physiology and increases health risks, but does so differentially in the sexes; however further study is necessary to establish causation.
Language eng
DOI 10.1002/dev.21275
Field of Research 1701 Psychology
1702 Cognitive Science
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077820

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 17 times in TR Web of Science
Scopus Citation Count Cited 17 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 315 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Wed, 06 Jan 2016, 11:23:53 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.