Effects of omega-3 PUFA on the vitamin E and glutathione antioxidant defense system in individuals at ultra-high risk of psychosis

Smesny, Stefan, Milleit, Berko, Schaefer, Miriam R., Hipler, Uta-Christina, Milleit, Christine, Wiegand, Cornelia, Hesse, Jana, Klier, Claudia M., Holub, Magdalena, Holzer, Ingrid, Berk, Michael, McGorry, Patrick D., Sauer, Heinrich and Amminger, G. Paul 2015, Effects of omega-3 PUFA on the vitamin E and glutathione antioxidant defense system in individuals at ultra-high risk of psychosis, Prostaglandins leukot essent fatty acids, vol. 101, pp. 15-21, doi: 10.1016/j.plefa.2015.07.001.

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Title Effects of omega-3 PUFA on the vitamin E and glutathione antioxidant defense system in individuals at ultra-high risk of psychosis
Author(s) Smesny, Stefan
Milleit, Berko
Schaefer, Miriam R.
Hipler, Uta-Christina
Milleit, Christine
Wiegand, Cornelia
Hesse, Jana
Klier, Claudia M.
Holub, Magdalena
Holzer, Ingrid
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
McGorry, Patrick D.
Sauer, Heinrich
Amminger, G. Paul
Journal name Prostaglandins leukot essent fatty acids
Volume number 101
Start page 15
End page 21
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-07-21
ISSN 1532-2823
Keyword(s) At-risk mental state
Follow-up
Longitudinal
Omega-3 fatty acids
Oxidative stress
Schizophrenia
Summary BACKGROUND: Oxidative stress and impaired antioxidant defenses are reported in schizophrenia and are associated with disturbed neurodevelopment, brain structural alterations, glutamatergic imbalance, increased negative symptoms, and cognitive impairment. There is evidence that oxidative stress predates the onset of acute psychotic illness. Here, we investigate the effects of omega-3 PUFA on the vitamin E and glutathione antioxidant defense system (AODS). METHOD: In 64 help-seeking UHR-individuals (13-25 years of age), vitamin E levels and glutathione were investigated before and after 12 weeks of treatment with either 1.2g/d omega-3 (PUFA-E) or saturated fatty acids (SFA-E), with each condition also containing 30.4mg/d alpha-tocopherol to ensure absorption without additional oxidative risk. RESULTS: In multivariate tests, the effects on the AODS (alpha-tocopherol, total glutathione) were not significantly different (p=0.13, p=0.11, respectively) between treatment conditions. According to univariate findings, only PUFA-E caused a significant alpha-tocopherol increase, while PUFA-E and SFA-E caused a significant gamma- and delta-tocopherol decrease. Total glutathione (GSHt) was decreased by PUFA-E supplementation. CONCLUSION: Effects of the PUFA-E condition on the vitamin E and glutathione AODS could be mechanisms underlying its clinical effectiveness. In terms of the vitamin E protection system, PUFA-E seems to directly support the antioxidative defense at membrane level. The effect of PUFA-E on GSHt is not yet fully understood, but could reflect antioxidative effects, resulting in decreased demand for glutathione. It is still necessary to further clarify which type of PUFA/antioxidant combination, and in which dose, is effective at each stage of psychotic illness.
Language eng
DOI 10.1016/j.plefa.2015.07.001
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077926

Document type: Journal Article
Collection: School of Medicine
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