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Comparison of anthropometric measures as predictors of cancer incidence: a pooled collaborative analysis of 11 Australian cohorts

Harding, Jessica L, Shaw, Jonathan E., Anstey, Kaarin J., Adams, Robert, Balkau, Beverley, Brennan-Olsen, Sharon L., Briffa, Tom, Davis, Timothy M.E., Davis, Wendy A., Dobson, Annette, Flicker, Leon, Giles, Graham, Grant, Janet, Huxley, Rachel, Knuiman, Matthew, Luszcz, Mary, MacInnis, Robert J., Mitchell, Paul, Pasco, Julie A., Reid, Christopher, Simmons, David, Simons, Leon, Tonkin, Andrew, Woodward, Mark, Peeters, Anna and Magliano, Dianna J. 2015, Comparison of anthropometric measures as predictors of cancer incidence: a pooled collaborative analysis of 11 Australian cohorts, International journal of cancer, vol. 137, no. 7, pp. 1699-1708, doi: 10.1002/ijc.29529.

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Title Comparison of anthropometric measures as predictors of cancer incidence: a pooled collaborative analysis of 11 Australian cohorts
Author(s) Harding, Jessica L
Shaw, Jonathan E.
Anstey, Kaarin J.
Adams, Robert
Balkau, Beverley
Brennan-Olsen, Sharon L.
Briffa, Tom
Davis, Timothy M.E.
Davis, Wendy A.
Dobson, Annette
Flicker, Leon
Giles, Graham
Grant, Janet
Huxley, Rachel
Knuiman, Matthew
Luszcz, Mary
MacInnis, Robert J.
Mitchell, Paul
Pasco, Julie A.
Reid, Christopher
Simmons, David
Simons, Leon
Tonkin, Andrew
Woodward, Mark
Peeters, Anna
Magliano, Dianna J.
Journal name International journal of cancer
Volume number 137
Issue number 7
Start page 1699
End page 1708
Total pages 10
Publisher Wiley
Place of publication Weinheim, Germany
Publication date 2015
ISSN 1097-0215
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Oncology
BODY-MASS INDEX
HORMONE REPLACEMENT THERAPY
DOSE-RESPONSE METAANALYSIS
TO-HEIGHT RATIO
WAIST CIRCUMFERENCE
BREAST-CANCER
COLORECTAL-CANCER
CARDIOVASCULAR-DISEASE
SCREENING TOOL
HIP RATIO
Summary Obesity is a risk factor for cancer. However, it is not known if general adiposity, as measured by body mass index (BMI) or central adiposity [e.g., waist circumference (WC)] have stronger associations with cancer, or which anthropometric measure best predicts cancer risk. We included 79,458 men and women from the Australian and New Zealand Diabetes and Cancer Collaboration with complete data on anthropometry [BMI, WC, Hip Circumference (HC), WHR, waist to height ratio (WtHR), A Body Shape Index (ABSI)], linked to the Australian Cancer Database. Cox proportional hazards models assessed the association between each anthropometric marker, per standard deviation and the risk of overall, colorectal, post-menopausal (PM) breast, prostate and obesity-related cancers. We assessed the discriminative ability of models using Harrell's c-statistic. All anthropometric markers were associated with overall, colorectal and obesity-related cancers. BMI, WC and HC were associated with PM breast cancer and no significant associations were seen for prostate cancer. Strongest associations were observed for WC across all outcomes, excluding PM breast cancer for which HC was strongest. WC had greater discrimination compared to BMI for overall and colorectal cancer in men and women with c-statistics ranging from 0.70 to 0.71. We show all anthropometric measures are associated with the overall, colorectal, PM breast and obesity-related cancer in men and women, but not prostate cancer. WC discriminated marginally better than BMI. However, all anthropometric measures were similarly moderately predictive of cancer risk. We do not recommend one anthropometric marker over another for assessing an individuals' risk of cancer.
Language eng
DOI 10.1002/ijc.29529
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077942

Document type: Journal Article
Collections: School of Health and Social Development
School of Medicine
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