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The epidemiology of incident fracture from cradle to senescence

Pasco, Julie A., Lane, Stephen E., Brennan-Olsen, Sharon L, Holloway, Kara L., Timney, Elizabeth N., Bucki-Smith, Gosia, Morse, Amelia G., Dobbins, Amelia G., Williams, Lana J., Hyde, Natalie K. and Kotowicz, Mark A. 2015, The epidemiology of incident fracture from cradle to senescence, Calcified tissue international, vol. 97, no. 6, pp. 568-576, doi: 10.1007/s00223-015-0053-y.

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Title The epidemiology of incident fracture from cradle to senescence
Author(s) Pasco, Julie A.ORCID iD for Pasco, Julie A. orcid.org/0000-0002-8968-4714
Lane, Stephen E.
Brennan-Olsen, Sharon L
Holloway, Kara L.
Timney, Elizabeth N.
Bucki-Smith, Gosia
Morse, Amelia G.ORCID iD for Morse, Amelia G. orcid.org/0000-0003-0267-4175
Dobbins, Amelia G.
Williams, Lana J.
Hyde, Natalie K.
Kotowicz, Mark A.ORCID iD for Kotowicz, Mark A. orcid.org/0000-0002-8094-1411
Journal name Calcified tissue international
Volume number 97
Issue number 6
Start page 568
End page 576
Total pages 9
Publisher Springer
Place of publication Berlin, Germany
Publication date 2015-12
ISSN 1432-0827
Keyword(s) Epidemiology
Fracture
Fracture incidence
Injury
Osteoporosis
Summary To reduce the burden of fracture, not only does bone fragility need to be addressed, but also injury prevention. Thus, fracture epidemiology irrespective of degree of trauma is informative. We aimed to determine age-and-sex-specific fracture incidence rates for the Barwon Statistical Division, Australia, 2006-2007. Using radiology reports, incident fractures were identified for 5342 males and 4512 females, with incidence of 210.4 (95 % CI 204.8, 216.2) and 160.0 (155.3, 164.7)/10,000/year, respectively. In females, spine (clinical vertebral), hip (proximal femoral) and distal forearm fractures demonstrated a pattern of stable incidence through early adult life, with an exponential increase beginning in postmenopausal years for fractures of the forearm followed by spine and hip. A similar pattern was observed for the pelvis, humerus, femur and patella. Distal forearm, humerus, other forearm and ankle fractures showed incidence peaks during childhood and adolescence. For males, age-related changes mimicked the female pattern for fractures of the spine, hip, ribs, pelvis and humerus. Incidence at these sites was generally lower for males, particularly among the elderly. A similar childhood-adolescent peak was seen for the distal forearm and humerus. For ankle fractures, there was an increase during childhood and adolescence but this extended into early adult life; in contrast to females, there were no further age-related increases. An adolescent-young adult peak incidence was observed for fractures of the face, clavicle, carpal bones, hand, fingers, foot and toe, without further age-related increases. Examining patterns of fracture provides the evidence base for monitoring temporal changes in fracture burden, and for identifying high-incidence groups to which fracture prevention strategies could be directed.
Language eng
DOI 10.1007/s00223-015-0053-y
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30077943

Document type: Journal Article
Collection: School of Medicine
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