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Movement-related potentials in high-functioning autism and Asperger's disorder

Rinehart, Nicole J., Tonge, Bruce, Bradshaw, John L., Iansek, Robert, Enticott, Peter G. and Johnson, Katherine A. 2006, Movement-related potentials in high-functioning autism and Asperger's disorder, Developmental medicine and child neurology, vol. 48, no. 4, pp. 272-277, doi: 10.1017/S0012162206000594.

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Title Movement-related potentials in high-functioning autism and Asperger's disorder
Author(s) Rinehart, Nicole J.ORCID iD for Rinehart, Nicole J. orcid.org/0000-0001-6109-3958
Tonge, Bruce
Bradshaw, John L.
Iansek, Robert
Enticott, Peter G.ORCID iD for Enticott, Peter G. orcid.org/0000-0002-6638-951X
Johnson, Katherine A.
Journal name Developmental medicine and child neurology
Volume number 48
Issue number 4
Start page 272
End page 277
Total pages 6
Publisher Wiley-Blackwell
Place of publication Chichester, Eng.
Publication date 2006-04
ISSN 0012-1622
Keyword(s) Adolescent
Adult
Asperger Syndrome
Autistic Disorder
Child
Child, Preschool
Diagnosis, Computer-Assisted
Electroencephalography
Evoked Potentials, Motor
Female
Humans
Male
Motor Cortex
Movement Disorders
Social Behavior
Summary Autism and Asperger's disorder (AD) are neurodevelopmental conditions that affect cognitive and social-communicative function. Using a movement-related potential (MRP) paradigm, we investigated the clinical and neurobiological issue of 'disorder separateness' versus 'disorder variance' in autism and AD. This paradigm has been used to assess basal ganglia/supplementary motor functioning in Parkinson's disease. Three groups (high functioning autism [HFA]: 16 males, 1 female; mean age 12y 5mo [SD 4y 4mo]; AD: 11 males, 2 females; mean age 13y 5mo [SD 3y 8mo]; comparison group: 13 males, 8 females; mean age 13y 10mo [SD 3y 11mo]) completed a cued motor task during electroencephalogram recording of MRPs. The HFA group showed reduced peak amplitude at Cz, indicating less activity over the supplementary motor area during movement preparation. Although an overall significant between-group effect was found for early slope and peak amplitude, sub-analysis revealed that the group with AD did not differ significantly from either group. However, it is suggested that autism and AD may be dissociated on the basis of brain-behaviour correlations of IQ with specific neurobiological measures. The overlap between MRP traces for autism and Parkinson's disease suggests that the neurobiological wiring of motor functioning in autism may bypass the supplementary motor area/primary motor cortex pathway.
Language eng
DOI 10.1017/S0012162206000594
Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified
11 Medical And Health Sciences
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Wiley-Blackwell
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078048

Document type: Journal Article
Collection: School of Psychology
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