Hypothalamo-pituitary adrenal axis and sympatho-adrenal medullary system responses to psychological stress were not attenuated in women with elevated physical fitness levels

Jayasinghe, Sisitha U., Lambert, Gavin W., Torres, Susan J., Fraser, Steve F., Eikelis, Nina and Turner, Anne I. 2016, Hypothalamo-pituitary adrenal axis and sympatho-adrenal medullary system responses to psychological stress were not attenuated in women with elevated physical fitness levels, Endocrine, vol. 51, no. 2, pp. 369-379, doi: 10.1007/s12020-015-0687-6.

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Title Hypothalamo-pituitary adrenal axis and sympatho-adrenal medullary system responses to psychological stress were not attenuated in women with elevated physical fitness levels
Author(s) Jayasinghe, Sisitha U.
Lambert, Gavin W.
Torres, Susan J.ORCID iD for Torres, Susan J. orcid.org/0000-0002-2599-1934
Fraser, Steve F.ORCID iD for Fraser, Steve F. orcid.org/0000-0003-0202-9619
Eikelis, Nina
Turner, Anne I.ORCID iD for Turner, Anne I. orcid.org/0000-0002-0682-2860
Journal name Endocrine
Volume number 51
Issue number 2
Start page 369
End page 379
Total pages 11
Publisher Springer
Place of publication New York, N.Y.
Publication date 2016-02
ISSN 1559-0100
Keyword(s) Fitness
Stress
TSST
Women
Summary It is not clear if higher levels of cardiorespiratory fitness are associated with lower hypothalamo-pituitary adrenal (HPA) axis and sympatho-adrenal medullary (SAM) system reactivity to psychological stress in women. The association between cardio-metabolic risk markers and acute physiological responses to psychological stress in women who differ in their cardiorespiratory fitness status has also not been investigated. Women with high (n = 22) and low (n = 22) levels of fitness aged 30-50 years (in the mid-follicular phase of the menstrual cycle) were subjected to a Trier Social Stress Test (TSST) at 1500 h. Plasma concentrations of cortisol, adrenaline (Adr), noradrenaline (NA), and dopamine (DA) were measured in samples collected every 7-15 min from 1400 to 1700 h. Heart rate and blood pressure were measured at the same time points. Low-fit women had elevated serum triglyceride, cholesterol/HDL ratio, fasting glucose, and HOMA-IR levels compared with high-fit women. While cortisol, Adr, NA, HR, and blood pressure all demonstrated a significant response to the TSST, the responses of these variables did not differ significantly between high- and low-fit women in response to the TSST. Dopamine reactivity was significantly higher in the low-fit women compared with high-fit women. There was also a significant negative correlation between VO2 max and DA reactivity. These findings suggest that, for low-fit women aged 30-50 years, the response of HPA axis and SAM system to a potent acute psychological stressor is not compromised compared to that in high-fit women.
Language eng
DOI 10.1007/s12020-015-0687-6
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920507 Women's Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078060

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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