Inflammatory bowel disease: pathogenesis, causative factors, issues, drug treatment strategies, and delivery approaches

Singh, Deependra, Srivastava, Shikha, Pradhan, Madhulika, Kanwar, Jagat R. and Singh, Manju Rawat 2015, Inflammatory bowel disease: pathogenesis, causative factors, issues, drug treatment strategies, and delivery approaches, Critical reviews in therapeutic drug carrier systems, vol. 32, no. 3, pp. 181-214, doi: 10.1615/CritRevTherDrugCarrierSyst.2015011095.

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Title Inflammatory bowel disease: pathogenesis, causative factors, issues, drug treatment strategies, and delivery approaches
Author(s) Singh, Deependra
Srivastava, Shikha
Pradhan, Madhulika
Kanwar, Jagat R.
Singh, Manju Rawat
Journal name Critical reviews in therapeutic drug carrier systems
Volume number 32
Issue number 3
Start page 181
End page 214
Total pages 34
Publisher Begell House
Place of publication Danbury, Conn.
Publication date 2015
ISSN 2162-660X
Keyword(s) animals
colitis, ulcerative
crohn disease
drug carriers
drug delivery systems
gastrointestinal agents
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
inflammatory bowel disease
colloidal carriers
stimuli-responsive systems
drug-delivery systems
Summary Inflammatory bowel disease (IBD) is an incessant, reverting, inflammatory disorder of the gastrointestinal tract encompassing two entities, namely, Crohn's disease (CD) and ulcerative colitis (UC). Numerous protocols have been explored to treat these dreadful diseases, including the use of different IBD drugs with different modes of action and routes of administration. Constant progression in the development of newer formulations, chemical modifications, stimuli-responsive systems, and novel approaches using colloidal and cellular carriers have led to effective treatments of gastric inflammation. Colloidal carriers including vesicular and particulate systems such as liposomes, transferosomes, solid lipid nanoparticles, microspheres; cellular carriers including erythrocytes, macrophages, and recombinant bacteria; and other systems such as osmotic pressure and plug control release have gained unique positions as drug carriers. Here, we investigate IBD in terms of its pathogenesis, role of genetic factors, currently available treatment options and their modes of action, pharmacokinetics, marketed products, side effects of individual IBD drugs, recent developments, modifications in the delivery of various drugs through novel colloidal drug carriers, and future prospects.
Language eng
DOI 10.1615/CritRevTherDrugCarrierSyst.2015011095
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Begell House
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Document type: Journal Article
Collection: School of Medicine
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