Self-assembly of monolayered lipid membranes for surface-coating of a nanoconfined Bombyx mori silk fibroin film

Xu, Fan, Bao, Meimei, Rui, Longfei, Liu, Jiaojiao, Li, Jingliang, Dou, Yujiang, Yang, Kai, Yuan, Bing and Ma, Yuqiang 2015, Self-assembly of monolayered lipid membranes for surface-coating of a nanoconfined Bombyx mori silk fibroin film, RSC advances, vol. 5, no. 81, pp. 65684-65689, doi: 10.1039/c5ra09683a.

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Title Self-assembly of monolayered lipid membranes for surface-coating of a nanoconfined Bombyx mori silk fibroin film
Author(s) Xu, Fan
Bao, Meimei
Rui, Longfei
Liu, Jiaojiao
Li, JingliangORCID iD for Li, Jingliang orcid.org/0000-0003-0709-2246
Dou, Yujiang
Yang, Kai
Yuan, Bing
Ma, Yuqiang
Journal name RSC advances
Volume number 5
Issue number 81
Start page 65684
End page 65689
Total pages 6
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2015
ISSN 2046-2069
Summary Regenerated Bombyx mori (B. mori) silk fibroin is a type of widely used biomaterial. The β-sheet structure of it after methanol treatment provides water-insolubility and mechanical stability while on the other side leads to a hydrophobic surface which is less preferred by biological systems. In this work we prepare a novel type of nanoconfined silk fibroin film with a thickness below 100 nm. The film has a flat while hydrophobic surface because of its β-sheet structure due to the z-direction confinement during formation. Different types of lipid monolayers, DOPC, DPPC and MO, are assembled on the silk film surface. The lipid coating, especially the DPPC membrane, provides a much smoother and more hydrophilic surface due to the gel phase tails of the lipids, in comparison with the DOPC and MO ones which are in a liquid phase and have a much stronger interfacial association between silk film surface and lipid tails. Such a lipid coating preserves the biocompatibility and cellular affinity of the silk film which promises potential applications as surface coatings for materials for biological use.
Language eng
DOI 10.1039/c5ra09683a
Field of Research 020405 Soft Condensed Matter
Socio Economic Objective 970102 Expanding Knowledge in the Physical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078121

Document type: Journal Article
Collection: Institute for Frontier Materials
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