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Properties of HIV-1 associated cholesterol in addition to raft formation are important for virus infection

Hawkes, David, Jones, Kate L., Smyth, Redmond P., Pereira, Cândida F., Bittman, Robert, Jaworowski, Anthony and Mak, Johnson 2015, Properties of HIV-1 associated cholesterol in addition to raft formation are important for virus infection, Virus research, vol. 210, pp. 18-21, doi: 10.1016/j.virusres.2015.06.023.

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Title Properties of HIV-1 associated cholesterol in addition to raft formation are important for virus infection
Author(s) Hawkes, David
Jones, Kate L.
Smyth, Redmond P.
Pereira, Cândida F.
Bittman, Robert
Jaworowski, Anthony
Mak, JohnsonORCID iD for Mak, Johnson orcid.org/0000-0002-5229-5707
Journal name Virus research
Volume number 210
Start page 18
End page 21
Total pages 4
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-12-02
ISSN 1872-7492
Keyword(s) Cholesterol
HIV
Lipid rafts
Viral entry
Virion membrane
Summary The overall HIV-1 membrane lipid contents resemble lipid rafts, and we have previously demonstrated that raft-promoting properties of virus-associated cholesterol (with modifications in either the 3β-OH group or AB rings) are important for HIV-1 infectivity. As cholesterol is present in both rafts and non-rafts domains of HIV-1 membrane, we question whether the interpretation of rafts property of virus-associated cholesterol being an absolute requirement for HIV-1 function is too simplistic. The carbon side chain of cholesterol is the third component of cholesterol that can affect the fluidity of membrane depending on its context within the lipid membrane bilayers. In this work, we have used synthetic cholesterol analogues that have different lengths of carbon side chain for our investigation. In contrast to our previous report, we have found that cholesterol side chain analogues that lack in vitro defined raft promoting-property is able to support HIV-1 replication. More specifically, cholesterol analogues with side chains of intermediate length have greater capacity to support HIV-1 infection, suggesting HIV-1 is able to maintain function using cholesterol variants that promote a range of non-rafts- to rafts-properties. Our data demonstrate cholesterol properties other than raft-promoting function also contribute to the infectivity of HIV-1.
Language eng
DOI 10.1016/j.virusres.2015.06.023
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078127

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 22 Oct 2015, 11:00:47 EST

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