The dopamine antagonist flupentixol does not alter ghrelin-induced food intake in rats

Engster, Kim-Marie, Wismar, Jamina, Kroczek, Arthur L., Teuffel, Pauline, Nolte, Sandra, Rose, Matthias, Stengel, Andreas and Kobelt, Peter 2015, The dopamine antagonist flupentixol does not alter ghrelin-induced food intake in rats, Neuropeptides, vol. 53, pp. 19-27, doi: 10.1016/j.npep.2015.08.007.

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Title The dopamine antagonist flupentixol does not alter ghrelin-induced food intake in rats
Author(s) Engster, Kim-Marie
Wismar, Jamina
Kroczek, Arthur L.
Teuffel, Pauline
Nolte, SandraORCID iD for Nolte, Sandra orcid.org/0000-0001-6185-9423
Rose, Matthias
Stengel, Andreas
Kobelt, Peter
Journal name Neuropeptides
Volume number 53
Start page 19
End page 27
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-10
ISSN 0143-4179
1532-2785
Keyword(s) Brain
Dopamine
Flupentixol
Food intake
Ghrelin
Rat
Summary It has been shown that dopamine antagonists suppress the ghrelin-induced increased motivation to work for food. The aim of this study was to investigate the influence of the dopamine antagonist flupentixol on ghrelin-induced food intake. Ad libitum fed male Sprague-Dawley (SD) rats were injected intraperitoneally (ip) with vehicle plus vehicle, vehicle plus ghrelin (13. μg/kg), 0.25. mg/kg or 0.5. mg/kg flupentixol plus ghrelin, or 0.25. mg/kg or 0.5 mg/kg flupentixol plus vehicle. In a second experiment, intracerebroventricularly (icv) cannulated rats received an ip injection of vehicle (0.15. M NaCl) or flupentixol (0.25. mg/kg) and 20. min later an icv injection of vehicle or ghrelin (1. μg/rat). Both experiments were performed twice: first, rats were offered only standard chow, while in the second experiment they could choose between standard chow and a palatable/preferred chow. Cumulative light phase food intake was assessed for 7. h. Ip as well as icv injected ghrelin reliably increased intake of standard chow. Flupentixol did not affect ghrelin-induced intake of standard chow. Ip injected ghrelin failed to increase the intake of palatable chow, whereas icv injected ghrelin did. This effect was not blocked by ip flupentixol. In summary, ip administered ghrelin did not increase the intake of chow the rats preferred; whereas icv injected ghrelin further stimulated the intake of preferred chow suggesting a direct central mediation of this effect. Our results show that the dopamine antagonist flupentixol does not influence ghrelin-induced feeding in our choice paradigm.
Language eng
DOI 10.1016/j.npep.2015.08.007
Field of Research 0601 Biochemistry And Cell Biology
1103 Clinical Sciences
1109 Neurosciences
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078160

Document type: Journal Article
Collection: School of Health and Social Development
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