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A non-destructive test to assess the axial heterogeneity of in situ modified monoliths for HPLC

Bassanese, Danielle N., Soliven, Arianne, Conlan, Xavier A., Shalliker, R. Andrew, Barnett, Neil W. and Stevenson, Paul G. 2015, A non-destructive test to assess the axial heterogeneity of in situ modified monoliths for HPLC, Analytical methods, vol. 7, no. 17, pp. 7177-7185, doi: 10.1039/c4ay02812k.

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Title A non-destructive test to assess the axial heterogeneity of in situ modified monoliths for HPLC
Author(s) Bassanese, Danielle N.
Soliven, Arianne
Conlan, Xavier A.ORCID iD for Conlan, Xavier A. orcid.org/0000-0003-0829-0551
Shalliker, R. Andrew
Barnett, Neil W.
Stevenson, Paul G.ORCID iD for Stevenson, Paul G. orcid.org/0000-0001-6780-6859
Journal name Analytical methods
Volume number 7
Issue number 17
Start page 7177
End page 7185
Total pages 9
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2015-01-01
ISSN 1759-9660
1759-9679
Summary This paper describes a non-destructive "peak parking" protocol in order to assess the axial heterogeneity of an in situ modified monolithic column for high performance liquid chromatography; a "gradient stationary phase" was designed whereby the ligand density decreases along the length of the rod in the "forward flow" configuration. The results of multi-location peak parking demonstrated a consistent increase in peak variance from the 1 cm position of the column to the 9 cm location. This increase in band broadening supported the theory of a decreasing ligand density along the length of this gradient column. This is consistent with efficiency measurements performed in both the forward and reverse flow directions, with an improved efficiency (15% increase in N m-1) in the reverse direction. These results are consistent with theoretical investigations into stationary phase gradients.
Language eng
DOI 10.1039/c4ay02812k
Field of Research 030108 Separation Science
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078256

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