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The impact of sleep restriction and simulated physical firefighting work on acute inflammatory stress responses

Wolkow, Alexander, Ferguson, Sally A., Vincent, Grace E., Larsen, Brianna, Aisbett, Brad and Main, Luana C. 2015, The impact of sleep restriction and simulated physical firefighting work on acute inflammatory stress responses, PLoS one, vol. 10, no. 9, pp. 1-17, doi: 10.1371/journal.pone.0138128.

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Title The impact of sleep restriction and simulated physical firefighting work on acute inflammatory stress responses
Author(s) Wolkow, Alexander
Ferguson, Sally A.
Vincent, Grace E.
Larsen, Brianna
Aisbett, BradORCID iD for Aisbett, Brad orcid.org/0000-0001-8077-0272
Main, Luana C.ORCID iD for Main, Luana C. orcid.org/0000-0002-9576-9466
Contributor(s) Lutter, R.
Journal name PLoS one
Volume number 10
Issue number 9
Start page 1
End page 17
Total pages 17
Publisher Public Library of Science (PLoS)
Place of publication San Francisco, Calif.
Publication date 2015
ISSN 1932-6203
Summary OBJECTIVES: This study investigated the effect restricted sleep has on wildland firefighters' acute cytokine levels during 3 days and 2 nights of simulated physical wildfire suppression work. METHODS: Firefighters completed multiple days of physical firefighting work separated by either an 8-h (Control condition; n = 18) or 4-h (Sleep restriction condition; n = 17) sleep opportunity each night. Blood samples were collected 4 times a day (i.e., 06:15, 11:30, 18:15, 21:30) from which plasma cytokine levels (IL-6, IL-8, IL-1β, TNF-α, IL-4, IL-10) were measured. RESULTS: The primary findings for cytokine levels revealed a fixed effect for condition that showed higher IL-8 levels among firefighters who received an 8-h sleep each night. An interaction effect demonstrated differing increases in IL-6 over successive days of work for the SR and CON conditions. Fixed effects for time indicated that IL-6 and IL-4 levels increased, while IL-1β, TNF-α and IL-8 levels decreased. There were no significant effects for IL-10 observed. CONCLUSION: Findings demonstrate increased IL-8 levels among firefighters who received an 8-h sleep when compared to those who had a restricted 4-h sleep. Firefighters' IL-6 levels increased in both conditions which may indicate that a 4-h sleep restriction duration and/or period (i.e., 2 nights) was not a significant enough stressor to affect this cytokine. Considering the immunomodulatory properties of IL-6 and IL-4 that inhibit pro-inflammatory cytokines, the rise in IL-6 and IL-4, independent of increases in IL-1β and TNF-α, could indicate a non-damaging response to the stress of simulated physical firefighting work. However, given the link between chronically elevated cytokine levels and several diseases, further research is needed to determine if firefighters' IL-8 and IL-6 levels are elevated following repeated firefighting deployments across a fire season and over multiple fire seasons.
Language eng
DOI 10.1371/journal.pone.0138128
Field of Research 111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Public Library of Science (PLoS)
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078408

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Created: Wed, 23 Sep 2015, 20:38:03 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.