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Comparative microarray analysis identifies commonalities in neuronal injury: evidence for oxidative stress, dysfunction of calcium signalling, and inhibition of autophagy-lysosomal pathway

Yap, Yann Wan, Llanos, Roxana M., La Fontaine, Sharon, Cater, Michael A., Beart, Philip M. and Cheung, Nam Sang 2016, Comparative microarray analysis identifies commonalities in neuronal injury: evidence for oxidative stress, dysfunction of calcium signalling, and inhibition of autophagy-lysosomal pathway, Neurochemical research, vol. 41, no. 3, First online, pp. 554-567, doi: 10.1007/s11064-015-1666-2.

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Title Comparative microarray analysis identifies commonalities in neuronal injury: evidence for oxidative stress, dysfunction of calcium signalling, and inhibition of autophagy-lysosomal pathway
Author(s) Yap, Yann Wan
Llanos, Roxana M.
La Fontaine, SharonORCID iD for La Fontaine, Sharon orcid.org/0000-0002-9948-074X
Cater, Michael A.
Beart, Philip M.
Cheung, Nam SangORCID iD for Cheung, Nam Sang orcid.org/0000-0001-9453-2523
Journal name Neurochemical research
Volume number 41
Issue number 3
Season First online
Start page 554
End page 567
Total pages 14
Publisher Springer
Place of publication New York, N.Y.
Publication date 2016-03
ISSN 1573-6903
Keyword(s) Rotenone
Lactacystin
NMDA
programmed cell death
Summary Mitochondrial dysfunction, ubiquitin-proteasomal system impairment and excitotoxicity occur during the injury and death of neurons in neurodegenerative conditions. The aim of this work was to elucidate the cellular mechanisms that are universally altered by these conditions. Through overlapping expression profiles of rotenone-, lactacystin- and N-methyl-D-aspartate-treated cortical neurons, we have identified three affected biological processes that are commonly affected; oxidative stress, dysfunction of calcium signalling and inhibition of the autophagic-lysosomal pathway. These data provides many opportunities for therapeutic intervention in neurodegenerative conditions, where mitochondrial dysfunction, proteasomal inhibition and excitotoxicity are evident.
Language eng
DOI 10.1007/s11064-015-1666-2
Field of Research 110902 Cellular Nervous System
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078540

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