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Experimental foot-and-mouth disease virus infection in white tailed deer

Moniwa, M., Embury-Hyatt, C., Zhang, Z., Hole, K., Clavijo, A., Copps, J. and Alexandersen, S. 2012, Experimental foot-and-mouth disease virus infection in white tailed deer, Journal of comparative pathology, vol. 147, no. 2-3, pp. 330-342, doi: 10.1016/j.jcpa.2012.01.010.

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Title Experimental foot-and-mouth disease virus infection in white tailed deer
Author(s) Moniwa, M.
Embury-Hyatt, C.
Zhang, Z.
Hole, K.
Clavijo, A.
Copps, J.
Alexandersen, S.ORCID iD for Alexandersen, S. orcid.org/0000-0002-5039-3178
Journal name Journal of comparative pathology
Volume number 147
Issue number 2-3
Start page 330
End page 342
Total pages 13
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2012-08
ISSN 0021-9975
1532-3129
Keyword(s) Experimental infection
Pathogenesis
Transmission
White tailed deer
Summary White tailed deer (Odocoileus virginianus) were inoculated with foot-and-mouth disease virus (FMDV) O UKG 11/2001 and monitored for the development of clinical signs, histopathological changes and levels of virus replication. All FMDV-infected deer developed clinical signs starting at 2 days post inoculation and characterized by an increase in body temperature, increased salivation and lesions in the mouth and on the feet. Virus spread to various tissues was determined by quantifying the amount of FMDV RNA using quantitative reverse transcriptase polymerase chain reaction. Virus or viral antigen was also detected in tissues using traditional isolation techniques, enzyme linked immunosorbent assay and immunohistochemistry. Deer-to-cattle transmission of the virus was observed in this experimental setting; however, inoculated deer were not found to become carriers of FMDV.
Language eng
DOI 10.1016/j.jcpa.2012.01.010
Field of Research 070712 Veterinary Virology
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078683

Document type: Journal Article
Collection: School of Medicine
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