Exercise, skeletal muscle and circulating microRNAs

Russell, Aaron P. and Lamon, Séverine 2015, Exercise, skeletal muscle and circulating microRNAs, Progress in molecular biology and translational science, vol. 135, pp. 471-496, doi: 10.1016/bs.pmbts.2015.07.018.

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Title Exercise, skeletal muscle and circulating microRNAs
Author(s) Russell, Aaron P.ORCID iD for Russell, Aaron P. orcid.org/0000-0002-7323-9501
Lamon, SéverineORCID iD for Lamon, Séverine orcid.org/0000-0002-3271-6551
Journal name Progress in molecular biology and translational science
Volume number 135
Start page 471
End page 496
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015
ISSN 1877-1173
1878-0814
Keyword(s) Endurance exercise
MicroRNA
Resistance exercise
Skeletal muscle
Summary Regular exercise stimulates numerous structural, metabolic, and morphological adaptations in skeletal muscle. These adaptations are vital to maintain human health over the life span. Exercise is therefore seen as a primary intervention to reduce the risk of chronic disease. Advances in molecular biology, biochemistry, and bioinformatics, combined with exercise physiology, have identified many key signaling pathways as well as transcriptional and translational processes responsible for exercise-induced adaptations. Noncoding RNAs, and specifically microRNAs (miRNAs), constitute a new regulatory component that may play a role in these adaptations. The short single-stranded miRNA sequences bind to the 3' untranslated region of specific messenger RNAs (mRNAs) on the basis of sequence homology. This results in the degradation of the target mRNA or the inhibition of protein translation causing repression of the corresponding protein. While tissue specificity or enrichment of certain miRNAs makes them ideal targets to manipulate and understand tissue development, function, health, and disease, other miRNAs are ubiquitously expressed; however, it is uncertain whether their mRNA/protein targets are conserved across different tissues. miRNAs are stable in plasma and serum and their altered circulating expression levels in disease conditions may provide important biomarker information. The emerging research into the role that miRNAs play in exercise-induced adaptations has predominantly focused on the miRNA species that are regulated in skeletal muscle or in circulation. This chapter provides an overview of these current research findings, highlights the strengths and weaknesses identified to date, and suggests where the exercise-miRNA field may move into the future.
Language eng
DOI 10.1016/bs.pmbts.2015.07.018
Field of Research 110602 Exercise Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078870

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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