Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance

Walker, Adam J., Foley, Brittany M., Sutor, Shari L., McGillivray, Jane A., Frye, Mark A. and Tye, Susannah J. 2015, Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance, Behavioural brain research, vol. 293, pp. 198-202, doi: 10.1016/j.bbr.2015.07.026.

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Title Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance
Author(s) Walker, Adam J.ORCID iD for Walker, Adam J. orcid.org/0000-0002-5399-1245
Foley, Brittany M.
Sutor, Shari L.
McGillivray, Jane A.ORCID iD for McGillivray, Jane A. orcid.org/0000-0003-2000-6488
Frye, Mark A.
Tye, Susannah J.
Journal name Behavioural brain research
Volume number 293
Start page 198
End page 202
Total pages 5
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-10-05
ISSN 0166-4328
1872-7549
Keyword(s) Adrenocorticotropic hormone (ACTH)
Animal model
C-reactive protein (CRP)
Cytokine
Ketamine
Treatment-resistant depression (TRD)
Summary © 2015 Elsevier B.V. Ketamine, N-methyl- d-aspartate (NMDA) receptor antagonist and anti-inflammatory agent, has rapid therapeutic effects in a subset of patients with more intractable forms of depression. Irregular proinflammatory cytokine and acute-reactive protein levels have been reported in clinical and preclinical depression research. We explored the association between the rapid antidepressant-like effects of ketamine and peripheral proinflammatory profile in a model of antidepressant-resistance. Male Wistar rats were pre-treated with ACTH-(1-24) 100. μg/d or saline (0.9%) for 14. d. Antidepressant-like effects were assessed with the forced swim test (FST). Ketamine (10. mg/kg) significantly reduced immobility duration in saline-pretreated control animals. In contrast, a divergent response was observed in ACTH-pretreated antidepressant resistant animals, with 50% responders and 50% non-responders. Plasma samples were analyzed via enzyme-linked immunosorbent assay (ELISA) for interleukin 6 (IL-6), tumour necrosis factor alpha (TNFα) and C-reactive protein (CRP). Levels of CRP and TNFα differentiated ketamine responders and non-responders.
Language eng
DOI 10.1016/j.bbr.2015.07.026
Field of Research 11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
170199 Psychology not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30078906

Document type: Journal Article
Collection: School of Psychology
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