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Expression of anti-viral shRNA molecules in transgenic zebrafish

Clarke, Brian 2015, Expression of anti-viral shRNA molecules in transgenic zebrafish, Ph.D. thesis, School of Medicine, Deakin Univeristy.

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Title Expression of anti-viral shRNA molecules in transgenic zebrafish
Author Clarke, Brian
Institution Deakin Univeristy
School School of Medicine
Faculty Faculty of Health
Degree type Research doctorate
Degree name Ph.D.
Thesis advisor Ward Alister C.ORCID iD for Ward Alister C. orcid.org/0000-0001-7945-7975
Date submitted 2015-04
Keyword(s) transgenic zebrafish
viral hemorrhagic septicemia virus
short-hairpin RNA interference
Summary  Development of transgenic zebrafish specifically resistant to Viral Hemorrhagic Septicemia Virus mediated by short-hairpin RNA interference. Introduction of shRNAs by Tol2 transgenisis in to zebrafish overwhelmed multiple facets of the endogenous microRNA pathway including Exportin-5 and Argonaute-2 and prevented normal zebrafish development.
Language eng
Field of Research 100102 Agricultural Marine Biotechnology
100104 Genetically Modified Animals
100109 Transgenesis
Socio Economic Objective 830102 Aquaculture Fin Fish (excl. Tuna)
Description of original xxiv, 228 pages : illustrations, tables
Copyright notice ┬ęThe Author. All Rights Reserved
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079001

Document type: Thesis
Collections: Higher degree theses (full text)
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Created: Wed, 14 Oct 2015, 15:28:28 EST by Kate Percival

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.