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Synthetic biology based metabolic engineering of saccharomyces cerevisiae for omega 6 and 3 PUFA production

Sonkar, Shailendra Pratap 2015, Synthetic biology based metabolic engineering of saccharomyces cerevisiae for omega 6 and 3 PUFA production, PhD thesis, School of Life and Environmental Sciences, Deakin Univeristy.

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Title Synthetic biology based metabolic engineering of saccharomyces cerevisiae for omega 6 and 3 PUFA production
Author Sonkar, Shailendra Pratap
Institution Deakin Univeristy
School School of Life and Environmental Sciences
Faculty Faculty of Science, Engineering and Built Environment
Degree type Research doctorate
Degree name PhD
Thesis advisor Barrow, Colin
Puri, Munish
Date submitted 2015-06
Keyword(s) metabolic engineering
polyunsaturated fatty acids (PUFAs)
sustainable PUFA sources
transgenic yeast
Summary Metabolic engineering of PUFA biosynthesis pathway using codon optimized DGA1 (Diacylglycerol acyltransferase), FAA3 (Acyl-CoA synthetase), desaturase genes named D9D, D12D, D5D, D6D, D17D and D6E elongase gene was studied in S. cerevisiae. Engineered yeast strains successfully demonstrated increase in lipid accumulation, and heterologous biosynthesis of linoleic, γ-linolenic, dihomo γ-linolenic, arachidonic and eicosapentaenoic acid.
Language eng
Field of Research 100399 Industrial Biotechnology not elsewhere classified
100306 Industrial Molecular Engineering of Nucleic Acids and Proteins
Socio Economic Objective 860105 Nutraceuticals and Functional Foods
Description of original xviii, 146, [71] pages : illustrations, tables, graphs, some coloured
Dewey Decimal Classification 579.563
Restricted until 2017-01-01
Copyright notice ┬ęThe author
Free to Read? No
Free to Read Start Date 2015-12-02
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079026

Document type: Thesis
Collection: Higher degree theses (citation only)
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Created: Fri, 16 Oct 2015, 13:23:10 EST by Kate Percival

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