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Molecular targets in arthritis and recent trends in nanotherapy

Roy, Kislay, Kanwar, Rupinder Kaur and Kanwar, Jagat Rakesh 2015, Molecular targets in arthritis and recent trends in nanotherapy, International journal of nanomedicine, vol. 10, pp. 5407-5420, doi: 10.2147/IJN.S89156.

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Title Molecular targets in arthritis and recent trends in nanotherapy
Author(s) Roy, Kislay
Kanwar, Rupinder Kaur
Kanwar, Jagat RakeshORCID iD for Kanwar, Jagat Rakesh orcid.org/0000-0003-3728-9568
Journal name International journal of nanomedicine
Volume number 10
Start page 5407
End page 5420
Total pages 14
Publisher Dove Medical Press
Place of publication Auckland, N. Z.
Publication date 2015
ISSN 1178-2013
Keyword(s) bovine lactoferrin
interleukin
nanoparticle
osteoarthritis
osteopontin
rheumatoid arthritis
Science & Technology
Life Sciences & Biomedicine
Nanoscience & Nanotechnology
Pharmacology & Pharmacy
Science & Technology - Other Topics
NECROSIS-FACTOR-ALPHA
REGULATORY T-CELLS
RHEUMATOID-ARTHRITIS
IN-VIVO
II COLLAGEN
MOUSE MODEL
SYNOVIAL FIBROBLASTS
ARTICULAR-CARTILAGE
CHONDROITIN SULFATE
PEPTIDE INHIBITOR
Summary Due to its severity and increasing epidemiology, arthritis needs no description. There are various forms of arthritis most of which are disabling, very painful, and common. In spite of breakthroughs in the field of drug discovery, there is no cure for arthritis that can eliminate the disease permanently and ease the pain. The present review focuses on some of the most successful drugs in arthritis therapy and their side effects. Potential new targets in arthritis therapy such as interleukin-1β, interleukin-17A, tumor necrosis factor alpha, osteopontin, and several others have been discussed here, which can lead to refinement of current therapeutic modalities. Mechanisms for different forms of arthritis have been discussed along with the molecules that act as potential biomarkers for arthritis. Due to the difficulty in monitoring the disease progression to detect the advanced manifestations of the diseases, drug-induced cytotoxicity, and problems with drug delivery; nanoparticle therapy has gained the attention of the researchers. The unique properties of nanoparticles make them highly attractive for the design of novel therapeutics or diagnostic agents for arthritis. The review also focuses on the recent trends in nanoformulation development used for arthritis therapy. This review is, therefore, important because it describes the relevance and need for more arthritis research, it brings forth a critical discussion of successful drugs in arthritis and analyses the key molecular targets. The review also identifies several knowledge gaps in the published research so far along with the proposal of new ideas and future directions in arthritis therapy.
Language eng
DOI 10.2147/IJN.S89156
Field of Research 110322 Rheumatology and Arthritis
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Dove Medical Press
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079045

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.