A ghrelin receptor agonist is an effective colokinetic in rats with diet-induced constipation

Pustovit, R.V., Furness, J.B. and Rivera, L.R. 2015, A ghrelin receptor agonist is an effective colokinetic in rats with diet-induced constipation, Neurogastroenterology & motility, vol. 27, no. 5, pp. 610-617, doi: 10.1111/nmo.12517.

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Title A ghrelin receptor agonist is an effective colokinetic in rats with diet-induced constipation
Author(s) Pustovit, R.V.
Furness, J.B.
Rivera, L.R.
Journal name Neurogastroenterology & motility
Volume number 27
Issue number 5
Start page 610
End page 617
Total pages 8
Publisher Wiley
Place of publication London, Eng.
Publication date 2015
ISSN 1350-1925
Keyword(s) Capromorelin
Low-fiber diet
Summary Background Despite constipation being a common problem, the treatments that are available have side effects and are only partly effective. Recent studies show that centrally penetrant ghrelin receptor agonists cause defecation in humans and other species. Here, we describe some features of a rat model of low fiber-induced constipation, and investigate the effectiveness of the ghrelin agonist, capromorelin. Methods Rats were given low-fiber diets for 5 weeks. Their colorectal responsiveness to distension and to a behavioral test, water avoidance and colon histology were compared to those of rats on a standard diet. Key Results After the low-fiber diet, distension of the colon produced fewer propulsive contractions, behaviorally induced defecation was reduced, and the lining of the colorectum was inflamed. However, capromorelin was similarly effective in causing defecation in constipated and non-constipated rats. Conclusions & Inferences Low-fiber diet in rats produces a constipation phenotype, characterized by reduced responsiveness of the colorectum to distension and to a behavioral stimulus of defecation, water avoidance. The effectiveness of capromorelin suggests that centrally penetrant ghrelin receptor stimulants may be effective in treating constipation.
Language eng
DOI 10.1111/nmo.12517
Field of Research 1103 Clinical Sciences
1109 Neurosciences
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079259

Document type: Journal Article
Collection: School of Medicine
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