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Differences in hormone localisation patterns of K and L type enteroendocrine cells in the mouse and pig small intestine and colon

Cho, Hyun-Jung, Kosari, Samin, Hunne, Billie, Callaghan, Brid, Rivera, Leni R., Bravo, David M. and Furness, John B. 2015, Differences in hormone localisation patterns of K and L type enteroendocrine cells in the mouse and pig small intestine and colon, Cell and tissue research, vol. 359, no. 2, pp. 693-698, doi: 10.1007/s00441-014-2033-3.

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Title Differences in hormone localisation patterns of K and L type enteroendocrine cells in the mouse and pig small intestine and colon
Author(s) Cho, Hyun-Jung
Kosari, Samin
Hunne, Billie
Callaghan, Brid
Rivera, Leni R.
Bravo, David M.
Furness, John B.
Journal name Cell and tissue research
Volume number 359
Issue number 2
Start page 693
End page 698
Total pages 6
Publisher Springer
Place of publication New York, N.Y.
Publication date 2015-02
ISSN 0302-766X
1432-0878
Keyword(s) L cells
K cells
Gastrointestinal hormones
Glucagon-like insulinotropic peptide
Glucagon like peptide
Peptide YY
Summary  This study has investigated the patterns of colocalisation of the conventional K cell marker, glucagon-like insulinotropic peptide (GIP), and the L cell markers, glucagon like peptide-1 (GLP-1) and peptide YY (PYY), in enteroendocrine cells (EEC) of the small intestine and colon of mouse and pig. All combinations of the hormones, 3 in a cell, 2 in a cell and 1 at a time, were encountered. In both species, the three most common EEC types contained (1) both GLP-1 and PYY but not GIP, (2) GLP-1 alone or (3) GIP plus GLP-1 without PYY. Few GIP plus PYY cells and rare cells containing all 3 hormones were encountered. Gradients of cell types occurred along the intestine. For example, in mouse, there were no PYY cells in the duodenum and few in the jejunum, but >50 % of labelled EEC in the distal ileum and colon were PYY immunoreactive. By contrast, over 40 % of EEC in the pig duodenum contained PYY, and most also contained either GLP-1 or GIP. The gradient in pig was less pronounced. It is concluded that the traditional classification of K and L cells requires revision, and that there are major inter-species differences in the patterns of colocalisation of hormones that have been used to characterise K and L cells.
Language eng
DOI 10.1007/s00441-014-2033-3
Field of Research 1116 Medical Physiology
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079261

Document type: Journal Article
Collection: School of Medicine
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Created: Tue, 03 Nov 2015, 12:58:03 EST

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